Engineering dynamic systems or materials to respond to biological process is one of the major tasks in synthetic biology and will enable wide promising applications, such as robotics and smart medicine. Herein, a super‐soft and dynamic DNA/dopamine‐grafted‐dextran hydrogel, which shows super‐fast volume‐responsiveness with high sensitivity upon solvents with different polarities and enables creation of electric circuits in response to microbial metabolism is reported. Synergic permanent and dynamic double networks are integrated in this hydrogel. A serials of dynamic hydrogel‐based electric circuits are fabricated: 1) triggered by using water as switch, 2) triggered by using water and petroleum ether as switch pair, 3) a self‐healing electric circuit; 4) remarkably, a microbial metabolism process which produces ethanol triggering electric circuit is achieved successfully. It is envisioned that the work provides a new strategy for the construction of dynamic materials, particularly DNA‐based biomaterials; and the electric circuits will be highly promising in applications, such as soft robotics and intelligent systems.

中文翻译：

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超软 DNA/多巴胺接枝葡聚糖水凝胶作为微生物代谢过程开关电路的动态导线。

设计响应生物过程的动态系统或材料是合成生物学的主要任务之一，并将实现广泛有前景的应用，例如机器人和智能医学。在此，报道了一种超柔软、动态的DNA/多巴胺接枝葡聚糖水凝胶，它对不同极性的溶剂表现出超快的体积响应性和高灵敏度，并且能够创建响应微生物代谢的电路。这种水凝胶集成了协同的永久和动态双网络。制造了一系列基于动态水凝胶的电路：1）使用水作为开关触发，2）使用水和石油醚作为开关对触发，3）自愈电路；4)引人注目的是，成功实现了产生乙醇触发电路的微生物代谢过程。预计这项工作为构建动态材料，特别是基于 DNA 的生物材料提供了一种新策略；该电路在软机器人和智能系统等应用中将具有广阔的前景。