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Heterogeneity in mRNA Translation.
Trends in Cell Biology ( IF 19.0 ) Pub Date : 2020-05-25 , DOI: 10.1016/j.tcb.2020.04.008
Stijn Sonneveld 1 , Bram M P Verhagen 1 , Marvin E Tanenbaum 1
Affiliation  

During mRNA translation, the genetic information stored in mRNA is translated into a protein sequence. It is imperative that the genetic information is translated with high precision. Surprisingly, however, recent experimental evidence has demonstrated that translation can be highly heterogeneous, even among different mRNA molecules derived from a single gene in an individual cell; multiple different polypeptides can be produced from a single mRNA molecule and the rate of translation can vary in both space and time. However, whether translational heterogeneity serves an important cellular function, or rather predominantly represents gene expression ‘noise’ remains an open question. In this review, we discuss the molecular basis and potential functions of such translational heterogeneity.



中文翻译:

mRNA翻译中的异质性。

在mRNA翻译过程中,存储在mRNA中的遗传信息被翻译成蛋白质序列。遗传信息的翻译非常重要。但是,令人惊讶的是,最近的实验证据表明,即使在单个细胞中源自单个基因的不同mRNA分子之间,翻译也可能高度异质。单个mRNA分子可以产生多种不同的多肽,并且翻译的速度可以在空间和时间上变化。但是,翻译异质性是否发挥重要的细胞功能,还是主要代表基因表达“噪声”仍是一个悬而未决的问题。在这篇综述中,我们讨论了这种翻译异质性的分子基础和潜在功能。

更新日期:2020-07-16
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