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Rethinking Cancer Immunotherapy by Embracing and Engineering Complexity.
Trends in Biotechnology ( IF 17.3 ) Pub Date : 2020-05-25 , DOI: 10.1016/j.tibtech.2020.05.003
Matthew H W Chin 1 , Eileen Gentleman 2 , Marc-Olivier Coppens 3 , Richard M Day 1
Affiliation  

The meteoric rise of cancer immunotherapy in the past decade has led to promising treatments for a number of hard-to-treat malignancies. In particular, adoptive T cell therapy has recently reached a major milestone with two products approved by the US FDA. However, the inherent complexity of cell-based immunotherapies means that their manufacturing time, cost, and controllability limit their effectiveness and geographic reach. One way to address these issues may lie in complementing the dominant, reductionistic mentality in modern medicine with complex systems thinking. In this opinion article, we identify key concepts from complexity theory to address manufacturing challenges in cell-based immunotherapies and raise the possibility of a unifying framework upon which future bioprocessing strategies may be designed.



中文翻译:

通过拥抱和工程复杂性重新思考癌症免疫疗法。

在过去十年中,癌症免疫疗法的迅速兴起为许多难以治疗的恶性肿瘤提供了有希望的治疗方法。尤其是过继性 T 细胞疗法最近达到了一个重要的里程碑,有两种产品获得了美国 FDA 的批准。然而,基于细胞的免疫疗法固有的复杂性意味着它们的制造时间、成本和可控性限制了它们的有效性和地理范围。解决这些问题的一种方法可能在于用复杂的系统思维来补充现代医学中占主导地位的还原论心态。在这篇意见文章中,我们从复杂性理论中确定了关键概念,以解决基于细胞的免疫疗法中的制造挑战,并提出了一个统一框架的可能性,在该框架上可以设计未来的生物加工策略。

更新日期:2020-05-25
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