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DLNO/DLCO ratio evolution under targeted therapy in patients with pulmonary hypertension.
Respiratory Physiology & Neurobiology ( IF 2.3 ) Pub Date : 2020-05-25 , DOI: 10.1016/j.resp.2020.103467
J Catella 1 , F Costes 2 , J B Gaultier 3 , I Court Fortune 4 , C Tulane 5 , E De Magalhaes 6 , S Accassat 6 , S Chomette-Ballereau 7 , C Chapelle 8 , L Bertoletti 9
Affiliation  

The ratio of the diffusing capacity of the lung for carbon monoxide (DLCO) and for nitric oxide (DLNO) measured simultaneously is modified in patients with precapillary pulmonary hypertension (PH). The potential impact of targeted therapy on the DLCO/DLNO ratio is unknown.

Simultaneous measurements of DLNO and DLCO were performed at baseline, 3–4 month follow-up (first evaluation) and 12-month follow-up (second evaluation) after initiation of targeted PH therapies in incident cases of precapillary PH. The main outcome was the change in DLNO/DLCO ratio under treatment between baseline and the first evaluation.

Twenty-nine patients were included (mean age: 66.8 years, 62.1% female). No significant change in the DLNO/DLCO ratio was found between baseline and the first evaluation. Similarly, no significant differences were noted with regard to changes in Dm or Vc, the DLNO/DLCO ratio in different patient subgroups, or in the 20 patients evaluated at the second follow-up.

Within the limitations of this study, the DLNO/DLCO ratio is not useful in monitoring the response to treatment in PH.



中文翻译:

肺动脉高压患者靶向治疗下DLNO/DLCO比值的演变。

在毛细血管前肺动脉高压 (PH) 患者中,同时测量的肺对一氧化碳 (DLCO) 和一氧化氮 (DLNO) 的扩散能力的比率进行了修改。靶向治疗对 DLCO/DLNO 比率的潜在影响尚不清楚。

DLNO 和 DLCO 的同时测量在基线、3-4 个月的随访(第一次评估)和 12 个月的随访(第二次评估)开始针对毛细血管前 PH 的事件病例进行靶向 PH 治疗后进行。主要结果是基线和第一次评估之间治疗下 DLNO/DLCO 比率的变化。

包括 29 名患者(平均年龄:66.8 岁,62.1% 为女性)。在基线和第一次评估之间没有发现 DLNO/DLCO 比率的显着变化。同样,在 Dm 或 Vc 的变化、不同患者亚组中的 DLNO/DLCO 比率或在第二次随访时评估的 20 名患者中,也没有发现显着差异。

在本研究的局限性内,DLNO/DLCO 比率在监测 PH 治疗的反应方面没有用。

更新日期:2020-05-25
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