Background

Rumination is a well-known risk factor for depression. It is also associated with negative and positive symptoms and suicidality in patients suffering from psychosis. However, no studies have addressed the effect of antipsychotics on rumination.

Methods

Using the Brooding Scale (BS), we investigated the effect of antipsychotics on rumination at the 6-month follow up in patients with first-episode psychosis (n = 257). The relationship between rumination and other clinical variables was explored by conducting a correlation analysis and structural equation modeling (SEM). The clinical characteristics and short-term outcomes were compared between high and low ruminators at 6 months.

Results

Significant reductions in rumination and various clinical variables were observed at the 6-month follow-up. A significant correlation was observed between rumination and the score on the positive subscale of the Positive and Negative Syndrome Scale (PANSS). A direct path between the PANSS score and rumination was identified by SEM. High ruminators had more severe psychopathology, experienced more childhood traumas, and took less exercise than low ruminators. The recovery rate at 6 months was higher in low ruminators than in high ruminators.

Conclusions

Our findings suggest that antipsychotics are beneficial for reducing rumination in patients with first-episode psychosis. The outcomes at the 6-month follow-up were better in low ruminators than high ruminators.

中文翻译：

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抗精神病药对首发精神病患者反刍的影响。

背景

反刍是众所周知的抑郁症危险因素。它还与精神病患者的阴性和阳性症状以及自杀倾向有关。然而，没有研究解决抗精神病药对反刍的影响。

方法

使用育雏量表 (BS)，我们在 6 个月的随访中研究了抗精神病药物对首发精神病患者 ( n  = 257)反刍的影响。通过进行相关分析和结构方程模型 (SEM) 来探索反刍与其他临床变量之间的关系。在 6 个月时比较高反刍和低反刍动物的临床特征和短期结果。

结果

在 6 个月的随访中观察到反刍和各种临床变量的显着减少。观察到反刍与阳性和阴性综合征量表 (PANSS) 的阳性分量表得分之间存在显着相关性。SEM 确定了 PANSS 评分和反刍之间的直接路径。与低反刍者相比，高反刍者有更严重的精神病理学，经历了更多的童年创伤，运动量也更少。低反刍动物的 6 个月恢复率高于高反刍动物。

结论

我们的研究结果表明，抗精神病药有利于减少首发精神病患者的反刍。低反刍者的 6 个月随访结果优于高反刍者。