Ageing Research Reviews ( IF 13.1 ) Pub Date : 2020-05-25 , DOI: 10.1016/j.arr.2020.101089 Vladimir Heiskanen 1 , Morgan Pfiffner 2 , Timo Partonen 3
Both sun exposure and serum vitamin D levels have been associated with lower risks of all-cause mortality and chronic age-related diseases, e.g., cancer, diabetes and cardiovascular disease, in epidemiological studies. These associations have mainly been ascribed to beneficial effects of vitamin D. However, a vast body of randomized controlled trials (RCTs) and Mendelian randomization studies have failed to confirm any major health benefits from vitamin D supplementation. In this review, we present tentative evidence showing that red and near-infrared light, both being present in sunlight, could explain the associations between sunlight exposure and better health status. Body irradiation with red and near-infrared light, usually termed as photobiomodulation (PBM), has demonstrated beneficial effects in animal models of chronic diseases. Beyond this, preliminary evidence from RCTs suggest potential clinical benefit from PBM for chronic diseases. PBM is currently being investigated in many pre-registered clinical trials, results of which will eventually clarify the role of red and near-infrared light in the prevention and treatment of common age-related chronic diseases.
中文翻译:
阳光与健康:通过红色和近红外光将焦点从维生素D3转移到光生物调节。
在流行病学研究中,阳光暴晒和血清维生素D水平与全因死亡率和慢性老年性疾病(例如癌症,糖尿病和心血管疾病)的较低风险相关。这些关联主要归因于维生素D的有益作用。但是,大量的随机对照试验(RCT)和孟德尔随机研究未能证实补充维生素D有任何主要的健康益处。在这篇综述中,我们提供了初步的证据,表明存在于阳光下的红色和近红外光可以解释阳光照射与更好的健康状况之间的关系。用红光和近红外光(通常称为光生物调节(PBM))进行人体照射,已在慢性疾病的动物模型中显示出有益的作用。除此之外,RCT的初步证据表明,PBM对于慢性病具有潜在的临床益处。目前,PBM正在许多预先注册的临床试验中进行研究,其结果最终将阐明红光和近红外光在预防和治疗常见的与年龄有关的慢性疾病中的作用。