Anxiety is a common neuropsychiatric symptom in Parkinson’s disease (PD). Until now, anxiety has been consistently related to cognitive deficits and severity of motor symptoms, whereas the association between anxiety and motor subtypes (TD-PD, tremor dominant and PIGD-PD, postural instability/gait disturbances dominant) revealed contrasting results. The present study aims to investigate the relationship between PD motor subtypes and anxiety and to explore whether the relationship between anxiety and cognitive deficits occurs in a specific PD motor subtype. Consecutive PD outpatients were recruited and divided into TD-PD and PIGD-PD groups according to Jankovic et al.’s criteria. All participants underwent a neuropsychological battery to evaluate anxiety, apathy, the global cognitive functioning, memory abilities, executive and visuo-constructional functions. Thirty-six patients with TD-PD and 35 patients with PIGD-PD were enrolled. The two groups did not differ on demographical and clinical variables. As for the severity of anxiety, no significant difference between the two groups was found. Regression analysis revealed that higher anxiety score was associated with poorer performance on constructional visuospatial test in both TD-PD and PIGD-PD. Clinical variables were not associated with anxiety in the two groups. Our findings indicated that the severity of anxiety was not associated with any PD motor subtypes. Moreover, regression analysis revealed that impaired visuo-constructional abilities are related to anxiety independently of PD motor subtypes. Since altered fronto-parietal network might be one of the pathogenetic mechanisms underpinning anxiety and constructional visuospatial deficits, the treatment of cognitive dysfunctions might reduce anxious symptoms.

焦虑症是帕金森氏病（PD）的常见神经精神症状。到目前为止，焦虑症一直与认知缺陷和运动症状的严重程度相关，而焦虑症与运动亚型（TD-PD，震颤为主和PIGD-PD，姿势不稳/步态障碍为主）之间的关联显示出相反的结果。本研究旨在调查PD运动亚型与焦虑之间的关系，并探讨在特定的PD运动亚型中是否发生焦虑与认知缺陷之间的关系。根据Jankovic等人的标准，招募连续的PD门诊患者，并将其分为TD-PD组和PIGD-PD组。所有参与者都接受了神经心理学的评估，以评估其焦虑，冷漠，整体认知功能，记忆能力，执行和视觉建设职能。纳入了TD-PD患者36例和PIGD-PD患者35例。两组在人口统计学和临床​​变量上没有差异。至于焦虑的严重程度，两组之间没有发现显着差异。回归分析显示，在TD-PD和PIGD-PD中，较高的焦虑评分与较差的建筑视觉空间测试性能有关。两组的临床变量均与焦虑无关。我们的发现表明，焦虑的严重程度与任何PD运动亚型均无关。此外，回归分析表明，视力建设能力受损与焦虑无关，与PD运动亚型无关。