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Insulin resistance, androgens, and lipids are gradually improved in an age-dependent manner in lean women with polycystic ovary syndrome: insights from a large Caucasian cohort.
Hormones ( IF 3.2 ) Pub Date : 2020-05-25 , DOI: 10.1007/s42000-020-00211-z
S Livadas 1 , D Macut 2 , C Bothou 3 , J Kuliczkowska-Płaksej 4 , A Vryonidou 5 , J Bjekic-Macut 6 , Z Mouslech 7 , A Milewicz 4 , D Panidis 8
Affiliation  

Purpose

Polycystic ovary syndrome (PCOS), considered a lifelong condition, manifests mainly as a cluster of hyperandrogenic symptoms during the early reproductive years, with the affected woman gradually developing an adverse cardiometabolic profile over the years. However, some data point to the possibility of differences in the evolution of PCOS according to a woman’s weight. The aim of the present study was to evaluate the metabolic and hormonal profiles of women with PCOS over time.

Methods

A total of 763 lean women with PCOS (BMI 20–25 kg/m2) and 376 controls were included. The study group was further divided into three age groups representing women post-adolescence, of reproductive age, and of late reproductive age. All subjects were assessed clinically, biochemically, and hormonally.

Results

Waist circumference, lipids, androgens, and insulin resistance index (homeostasis model assessment of IR index (HOMA-IR)) were significantly higher in the PCOS group compared with controls. Age subgroup analysis showed a progressive decrease of HOMA-IR and waist circumference, and lipid levels were comparable between PCOS and controls in all age groups. Androgens remained significantly higher in PCOS, but they gradually decreased through time. A significant negative association of age with waist circumference, androgens, insulin, and HOMA-IR was revealed. Univariate and multivariate regression analysis disclosed a strong correlation of HOMA-IR with age (p = 0.014, β − 0.19, SE coefficient 0.008) as a single parameter or in combination with total cholesterol (TC) (p < 0.001, age: β − 0.023, SE 0.10; TC: β 0.084, SE 0.027).

Conclusion

Insulin resistance, androgens, and lipids are gradually improved in an age-dependent manner in lean PCOS women. We hypothesize that if these women do not gain weight with the passage of time, there is a high probability that their cardiometabolic risk will be attenuated.



中文翻译:

患有多囊卵巢综合征的瘦女性的胰岛素抵抗、雄激素和脂质以年龄依赖性方式逐渐改善:来自大型白人队列的见解。

目的

多囊卵巢综合征 (PCOS) 被认为是一种终生疾病,主要表现为生育早期的一系列高雄激素症状,多年来,受影响的女性逐渐出现不利的心脏代谢特征。然而,一些数据表明,根据女性的体重,PCOS 的演变可能存在差异。本研究的目的是评估 PCOS 女性随时间推移的代谢和激素状况。

方法

总共包括 763 名患有 PCOS 的瘦女性(BMI 20–25 kg/m 2)和 376 名对照者。研究组进一步分为三个年龄组,分别代表青春期后、育龄期和育龄后期的女性。对所有受试者进行临床、生化和激素评估。

结果

与对照组相比,PCOS 组的腰围、脂质、雄激素和胰岛素抵抗指数(IR 指数的稳态模型评估(HOMA-IR))显着更高。年龄亚组分析显示 HOMA-IR 和腰围逐渐减少,所有年龄组的 PCOS 和对照组之间的脂质水平相当。雄激素在 PCOS 中仍然显着升高,但随着时间的推移逐渐减少。年龄与腰围、雄激素、胰岛素和 HOMA-IR 显着负相关。单变量和多变量回归分析揭示 HOMA-IR 与年龄(p  = 0.014,β - 0.19,SE 系数 0.008)作为单一参数或与总胆固醇 (TC) 组合的强相关性(p < 0.001,年龄:β - 0.023,SE 0.10;TC:β 0.084,SE 0.027)。

结论

瘦 PCOS 女性的胰岛素抵抗、雄激素和脂质以年龄依赖性方式逐渐改善。我们假设,如果这些女性随着时间的推移体重不增加,她们的心脏代谢风险很可能会减弱。

更新日期:2020-05-25
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