Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling.,Clinical Pharmacokinetics

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Prediction of Maternal and Fetal Pharmacokinetics of Dolutegravir and Raltegravir Using Physiologically Based Pharmacokinetic Modeling.
Clinical Pharmacokinetics ( IF 4.5 ) Pub Date : 2020-05-25 , DOI: 10.1007/s40262-020-00897-9
Xiaomei I Liu ₁ , Jeremiah D Momper ₂ , Natella Y Rakhmanina _{1,

3} , Dionna J Green ₄ , Gilbert J Burckart ₅ , Tim R Cressey _{6,

7,

8} , Mark Mirochnick ₉ , Brookie M Best ₂ , John N van den Anker _{1,

10} , André Dallmann _{10,

11}

Affiliation

Division of Clinical Pharmacology, Children's National Hospital, Washington, DC, USA.
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA, USA.
Elizabeth Glaser Pediatric AIDS Foundation, Washington, DC, USA.
Office of Pediatric Therapeutics, US Food and Drug Administration, Silver Spring, MD, USA.
Office of Clinical Pharmacology, US Food and Drug Administration, Silver Spring, MD, USA.
PHPT/IRD 174, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, Thailand.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
Boston University, School of Medicine, Boston, MA, USA.
Division of Pediatric Pharmacology and Pharmacometrics, University of Basel Children's Hospital, Basel, Switzerland.
Clinical Pharmacometrics, Bayer, Leverkusen, Germany.

Background

Predicting drug pharmacokinetics in pregnant women including placental drug transfer remains challenging. This study aimed to develop and evaluate maternal–fetal physiologically based pharmacokinetic models for two antiretroviral drugs, dolutegravir and raltegravir.

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