Curcumin-loaded lipid-core nanocapsules attenuates the immune challenge LPS-induced in rats: Neuroinflammatory and behavioral response in sickness behavior,Journal of Neuroimmunology

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Curcumin-loaded lipid-core nanocapsules attenuates the immune challenge LPS-induced in rats: Neuroinflammatory and behavioral response in sickness behavior
Journal of Neuroimmunology ( IF 3.3 ) Pub Date : 2020-08-01 , DOI: 10.1016/j.jneuroim.2020.577270
Marcelo Gomes de Gomes ₁ , Flavia Elizabete Guerra Teixeira ₁ , Felipe Barbosa de Carvalho ₁ , Camila Oliveira Pacheco ₁ , Manoel Rodrigues da Silva Neto ₁ , Renata Giacomeli ₁ , Juliana Bernera Ramalho ₂ , Renata Bem Dos Santos ₁ , William Borges Domingues ₃ , Vinicius Farias Campos ₃ , Sandra Elisa Haas ₁

Affiliation

The purpose of current study was to evaluate the effect of curcumin (CUR) loaded lipid-core nanocapsules (CUR-LNC) treatment on neuroinflammatory and behavioral alterations in a model of sickness behavior induced by lipopolysaccharide (LPS) in rats. Rats were treated with CUR-LNC and CUR daily for 14 days. After the last treatments, sickness behavior was induced with LPS. Sickness behavior LPS-induced was confirmed by behavioral tests, an increase in levels of proinflammatory cytokines, decrease in levels of IL-10, overexpression of IDO-1 and IDO-2. In conclusion, CUR-LNC treatment attenuated the neuroinflammatory and behavioral changes caused in sickness behavior model.

中文翻译：

姜黄素脂质核心纳米胶囊减弱 LPS 诱导的大鼠免疫挑战：疾病行为中的神经炎症和行为反应

本研究的目的是评估姜黄素 (CUR) 负载脂质核心纳米胶囊 (CUR-LNC) 治疗对脂多糖 (LPS) 诱导的大鼠疾病行为模型的神经炎症和行为改变的影响。大鼠每天接受 CUR-LNC 和 CUR 治疗，持续 14 天。最后一次治疗后，用LPS诱导疾病行为。LPS 诱导的疾病行为通过行为测试、促炎细胞因子水平增加、IL-10 水平降低、IDO-1 和 IDO-2 过表达得到证实。总之，CUR-LNC 治疗减弱了疾病行为模型中引起的神经炎症和行为变化。

更新日期：2020-08-01

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