The availability of biocompatible, anti-bacterial coatings is of extreme importance for the development of biomedical devices. However, it has proven to be difficult to achieve both biocompatibility and bactericidal properties simultaneously. In the present work, as a novel, alternative approach, a quaternary ammonium salt-based poly(N-isopropylacrylamide) (QAS-PNIPAM) microgel was used both as the bactericidal agent and as an anchor system for the attachment of a cyto-compatibility-enhancing component. QAS-PNIPAM microgels were first prepared as thin films on silicon wafer. The QAS component of the film, as well as having strong inherent bactericidal properties, also provided binding sites for attachment of a glycopolymer containing sulfonate groups via attractive electrostatic interactions. It was shown that introduction of the sugar units improved the cytocompatibility of the microgel film without compromising its bactericidal efficacy. It is proposed that such microgel coatings may serve more generally as intermediates for the attachment of biofunctional components to biomaterial surfaces.

生物相容性，抗菌涂层的可用性对于生物医学设备的开发极为重要。然而，事实证明很难同时实现生物相容性和杀菌性能。在本工作中，作为一种新颖的替代方法，基于季铵盐的聚（N-异丙基丙烯酰胺）（QAS-PNIPAM）微凝胶既用作杀菌剂，又用作固定细胞相容性的锚定系统。 -增强组件。QAS-PNIPAM微凝胶首先在硅片上制成薄膜。薄膜的QAS成分，以及具有很强的固有杀菌特性，还提供了结合位点，用于通过吸引人的静电相互作用连接包含磺酸盐基团的糖聚合物。结果表明，引入糖单元改善了微凝胶膜的细胞相容性而不损害其杀菌效力。提出了这样的微凝胶涂层可以更普遍地用作将生物功能组分附着于生物材料表面的中间体。