Gastric cancer represents one of the leading causes of cancer deaths worldwide. Helicobacter pylori (H. pylori) infection is the strongest risk factor associated with gastric cancer. Due to new molecular techniques allowing greater identification of stomach microbes, investigators are beginning to examine the role that bacteria other than H. pylori play in gastric cancer development. Recently, researchers have investigated how the composition of the gastric microbiota varies among individuals with various stages of gastric disease. Specific microbes residing in the stomach have been preferentially associated with gastric cancer patients compared to individuals with a healthy gastric mucosa. Studies conducted on the insulin-gastrin (INS-GAS) transgenic mouse model have provided additional insight into the association between the gastric microbiota and gastric cancer. The purpose of this article is to review the current state of literature on the relationship between the gastric microbiota and gastric cancer based on clinical studies performed to date.

胃癌是全世界癌症死亡的主要原因之一。幽门螺杆菌（H. pylori）感染是与胃癌相关的最强危险因素。由于新的分子技术可以更好地识别胃微生物，因此研究人员开始研究除幽门螺杆菌以外的细菌的作用。参与胃癌的发展。最近，研究人员研究了胃病不同阶段的个体中胃微生物群的组成如何变化。与具有健康胃粘膜的个体相比，存在于胃中的特定微生物优先与胃癌患者相关。对胰岛素-胃泌素（INS-GAS）转基因小鼠模型进行的研究为胃微生物群和胃癌之间的关联提供了更多见解。本文的目的是根据迄今为止进行的临床研究来回顾有关胃微生物群与胃癌之间关系的文献。