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Viridistratins A-C, Antimicrobial and Cytotoxic Benzo[j]fluoranthenes from Stromata of Annulohypoxylon viridistratum (Hypoxylaceae, Ascomycota).
Biomolecules ( IF 5.5 ) Pub Date : 2020-05-23 , DOI: 10.3390/biom10050805
Kevin Becker 1, 2 , Anna-Charleen Wessel 1 , J Jennifer Luangsa-Ard 3 , Marc Stadler 1, 2
Affiliation  

During the course of our search for novel biologically active metabolites from tropical fungi, we are using chemotaxonomic and taxonomic methodology for the preselection of interesting materials. Recently, three previously undescribed benzo[j]fluoranthenes (13) together with the known derivatives truncatones A and C (4, 5) were isolated from the stromata of the recently described species Annulohypoxylon viridistratum collected in Thailand. Their chemical structures were elucidated by means of spectral methods, including nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HR-MS). The new compounds, for which we propose the trivial names viridistratins A−C, exhibited weak-to-moderate antimicrobial and cytotoxic activities in cell-based assays.

中文翻译:

Viridistratins AC,抗菌和对细胞有毒的苯环[J]氟蒽类,来自间日花环线虫(Hypoxylaceae,Ascomycota)。

在寻找热带真菌新的具有生物活性的代谢物的过程中,我们正在使用化学分类学和分类学方法对有趣的材料进行预选。最近,三以前未描述苯并[ Ĵ ]荧蒽(1 - 3)与已知的衍生物truncatones A和C(一起45)从最近描述物种的子座分离Annulohypoxylon viridistratum在泰国收集。通过光谱方法阐明了它们的化学结构,包括核磁共振(NMR)光谱和高分辨率质谱(HR-MS)。我们建议使用其简单名称为viridistratins A-C的新化合物在基于细胞的测定中显示出弱至中度的抗菌和细胞毒性活性。
更新日期:2020-05-23
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