Periodontitis is inextricably linked to oxidative-reductive (redox) imbalance. However, little is still known about the resultant ability to scavenge oxygen free radicals in saliva and gingival crevicular fluid in patients with periodontitis. The multitude of enzymatic and non-enzymatic antioxidants and their synergistic effects cause an interest in the evaluation of the total antioxidative capacity. Thus, our study aimed to evaluate the total oxidative and antioxidative activity of gingival crevicular fluid and saliva in the periodontitis, as well as to relate these biomarkers to clinical indices of periodontopathy. Additionally, by calculating the oxidative stress index (OSI), the intensity of redox disturbances was also evaluated. Fifty-eight periodontitis patients were included in the study and divided into two subgroups depending on the severity of the disease. In the non-stimulated/stimulated saliva as well as a gingival crevicular fluid of the study group, we found significantly higher OSI and total oxidant status (TOS) as well as lower total antioxidant capacity (TAC). However, the ability to reduce iron ions (FRAP) was significantly lower only in stimulated and non-stimulated saliva of patients with periodontitis. The examined parameters correlated with the periodontium’s clinical condition, which indicates the exacerbation of the inflammatory process. However, TAC, TOS, OSI, and FRAP did not differentiate individual stages of periodontitis.

中文翻译：

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牙周炎患者龈沟液和唾液的总氧化和抗氧化能力：审查和临床研究。

牙周炎与氧化还原（氧化还原）失衡有着千丝万缕的联系。然而，关于牙周炎患者清除唾液和龈沟液中氧自由基的最终能力了解甚少。多种酶抗氧化剂和非酶抗氧化剂及其协同作用引起人们对总抗氧化能力的评价。因此，我们的研究旨在评估牙周炎中龈沟液和唾液的总氧化和抗氧化活性，并将这些生物标记物与牙周病的临床指标相关联。此外，通过计算氧化应激指数（OSI），还评估了氧化还原干扰的强度。本研究包括58名牙周炎患者，根据疾病的严重程度将其分为两个亚组。在研究组的未刺激/刺激的唾液以及龈沟液中，我们发现OSI和总氧化剂状态（TOS）显着较高，而总抗氧化剂能力（TAC）较低。但是，仅在牙周炎患者的经刺激和未经刺激的唾液中，还原铁离子（FRAP）的能力明显较低。检查的参数与牙周的临床状况相关，表明牙周炎的恶化。但是，TAC，TOS，OSI和FRAP不能区分牙周炎的各个阶段。我们发现OSI和总氧化剂状态（TOS）明显较高，而总抗氧化剂容量（TAC）较低。但是，仅在牙周炎患者的经刺激和未经刺激的唾液中，还原铁离子（FRAP）的能力明显较低。检查的参数与牙周的临床状况相关，表明牙周炎的恶化。但是，TAC，TOS，OSI和FRAP不能区分牙周炎的各个阶段。我们发现OSI和总氧化剂状态（TOS）明显较高，而总抗氧化剂能力（TAC）较低。但是，仅在牙周炎患者的经刺激和未经刺激的唾液中，还原铁离子（FRAP）的能力明显较低。检查的参数与牙周的临床状况相关，表明牙周炎的恶化。但是，TAC，TOS，OSI和FRAP不能区分牙周炎的各个阶段。这表明炎症过程加剧。但是，TAC，TOS，OSI和FRAP不能区分牙周炎的各个阶段。这表明炎症过程加剧。但是，TAC，TOS，OSI和FRAP不能区分牙周炎的各个阶段。