The release kinetics of bioactive agents from electrospun matrices is governed by several factors, such as the chemical composition and design of the release device. In this work, three different chemical formulations and two different product designs were developed to control the release of Aloe vera extract rich in aloin to skin lesions. The kinetics of aloin release from single layer electrospun materials formulated with polymers with different biodegradation rates (isolated PCL and PCL blended with PLLA or PDLG) was analyzed and compared to the behavior of a three-layer sequential electrospun PCL matrix in which only the intermediate layer contained the A. vera extract (PCL SW). The multilayered structure with the physically confined bioactive agent layer had the purpose then of both modulating aloin release and also of protecting it from direct light exposure. Thin films were obtained, all presenting high potential to be used as wound dressing components, with thickness values of 0.13–0.26 mm and homogeneous fibrous microstructure, capable of absorbing from 1.06 to 2.88 g of phosphate buffered saline per gram of matrix. The films were stable in the same buffer, showing a maximum mass loss of less than 8% after 7 days. The biomaterials presented tensile strength of 0.64–1.37 MPa and elongation at break of 277–375%. The most striking difference in behavior was in the release kinetics, which was much more controlled with the PCL SW structure than with the others, in which marked burst effect was observed. In this film, the release mechanism was associated with the diffusion of the bioactive agent, having also contributions from the electrospun matrix relaxation and dissolution.

生物活性剂从电纺丝基质中的释放动力学受多种因素控制，例如化学成分和释放装置的设计。在这项工作中，开发了三种不同的化学配方和两种不同的产品设计，以控制富含芦荟的芦荟提取物释放到皮肤损伤中。分析了由具有不同生物降解率的聚合物配制的单层电纺材料（分离的PCL和PCL与PLLA或PDLG共混）中芦荟素释放的动力学，并将其与三层顺序电纺PCL基质的行为进行了比较，其中只有中间层包含A. vera提取（PCL SW）。具有物理限制的生物活性剂层的多层结构的目的是既调节芦荟素的释放，又保护其免受直接光照射。得到的薄膜都具有很高的潜力，可用作伤口敷料组件，其厚度值为0.13-0.26 mm，且纤维结构均匀，每克基质可吸收1.06至2.88 g磷酸盐缓冲盐水。膜在相同缓冲液中稳定，在7天后显示最大质量损失小于8％。生物材料的抗拉强度为0.64-1.37 MPa，断裂伸长率为277-375％。行为上最显着的差异在于释放动力学，在PCL SW结构上，释放动力学要比在其他动力学上受控制得多，在PCL SW结构中，观察到明显的爆发效应。