Abstract Oxygen plays a critical role in human cell survival and proliferation; hence, it is an essential factor in cancer tumor propagation. In the literature, many studies have investigated the oxygen contribution to cell proliferation and tumor growth; however, lack of the studies considering the effect of blood oxygen solubility on the tumor growth is remarkably sensed among the literature. Accordingly, in this study, we investigated the effect of oxygen Bunsen solubility coefficient on the brain glioma growth, following continuum mechanics principles. A biomechanical simulation was conducted by assuming a compressible hyperelastic model of growth for spherical glioma tissue. Patient-specific MRI dataset was utilized to develop the geometry of the brain. An isotropic growth deformation tensor alongside oxygen and cell number concentration relations were applied to the simulation. The results demonstrated that the tumor maximum volume at the end of 90 days decreased from 1315.59 mm3 to 1236.43 mm3, as the increase of oxygen Bunsen solubility coefficient for 20 %. Thus, we concluded that the accessibility of oxygen with higher values of blood solubility lowers the risk of tumor sudden growth, which was verified in comparison to literature experiments.

中文翻译：

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考虑氧本生溶解系数影响的脑胶质瘤生长的生物力学模拟

摘要 氧气在人类细胞的存活和增殖中起着至关重要的作用。因此，它是癌症肿瘤传播的重要因素。在文献中，许多研究调查了氧对细胞增殖和肿瘤生长的贡献；然而，文献中明显缺乏考虑血氧溶解度对肿瘤生长影响的研究。因此，在本研究中，我们根据连续介质力学原理研究了氧本生溶解系数对脑胶质瘤生长的影响。通过假设球形胶质瘤组织的可压缩超弹性模型进行生物力学模拟。患者特定的 MRI 数据集用于开发大脑的几何形状。将各向同性生长变形张量以及氧和细胞数量浓度关系应用于模拟。结果表明，随着氧本生溶解系数增加20%，90天末肿瘤最大体积从1315.59 mm3减小到1236.43 mm3。因此，我们得出结论，血液溶解度值较高的氧气的可及性降低了肿瘤突然生长的风险，与文献实验相比，这一点得到了证实。