Objective

The purpose of this study was to examine factors associated with frailty in older cancer survivors.

Materials and methods

This is a cross-sectional study using data from the National Social Health and Aging Project (NSHAP) Wave 2, and includes an in-home, nationally representative sample of community-dwelling adults ≥50 years and older from the United States. Frailty score was computed for each individual using a modified 4-point scale based on the phenotypic frailty. Ordinal logistic regression was used to characterize the association between health-related, sociodemographic factors and frailty.

Results

Among the 3377 participants, 461 were cancer survivors (answered “yes” to “ever have cancer other than skin cancer”). A final sample of 394 cancer survivors were included: 59 participants (16.1%) were frail, 219 participants were pre-frail (59.8%), and 88 participants were non-frail (24.0%). The univariate analyses showed increasing age (OR 1.48; CI 1.29–1.72; p-value <.001), comorbidities (OR 1.43; CI 1.25–1.64; p-value <.001), depression (OR 1.27; CI 1.19–1.35; p-value <.001) and low mobility (OR 1.55; CI 1.37–1.78; p-value <.001) were associated with frailty. Participants with high self-rated (good/very good/ excellent) physical health (OR 0.18; CI 0.11–0.30; p < .001) and mental health (OR 0.27; CI 0.15–0.50; p < .001) were less likely to be frail. In a multivariate model, frailty was associated with age, self-rated physical health, depression, ability to perform activities of daily living, and mobility (p < .05).

Conclusion

The findings highlight the importance of incorporating geriatric assessment into cancer survivorship to prevent and delay the progression of frailty.

中文翻译：

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与老年癌症幸存者身体虚弱相关的健康和社会人口因素。

客观的

本研究的目的是检查与老年癌症幸存者虚弱相关的因素。

材料和方法

这是一项横断面研究，使用来自美国国家社会健康和老龄化项目 (NSHAP) Wave 2 的数据，其中包括来自美国的 50 岁及以上社区居民的家庭、具有全国代表性的样本。使用基于表型虚弱的修改后的 4 点量表计算每个个体的虚弱评分。序数逻辑回归用于表征健康相关、社会人口因素和虚弱之间的关联。

结果

在 3377 名参与者中，461 人是癌症幸存者（对“曾患过皮肤癌以外的癌症”回答“是”）。最终样本包括 394 名癌症幸存者：59 名参与者 (16.1%) 体弱，219 名参与者体弱前 (59.8%)，88 名参与者非体弱 (24.0%)。单变量分析显示年龄增加（OR 1.48；CI 1.29–1.72；p值 <.001）、合并症（OR 1.43；CI 1.25–1.64；p 值 <.001）、抑郁症（OR 1.27；CI 1.19–1.35 ; p 值 <.001）和低流动性（OR 1.55；CI 1.37–1.78；p 值 <.001）与虚弱相关。自我评价高（好/非常好/优秀）身体健康的参与者（OR 0.18；CI 0.11-0.30；p < .001）和心理健康（OR 0.27；CI 0.15–0.50；p < .001）不太可能虚弱。在多变量模型中，虚弱与年龄、自评身体健康、抑郁、日常生活活动能力和活动能力相关（p  < .05）。

结论

研究结果强调了将老年病评估纳入癌症生存期以预防和延缓衰弱进展的重要性。