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Glycogen synthase kinase-3 signaling in cellular and behavioral responses to psychostimulant drugs.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ( IF 5.1 ) Pub Date : 2020-05-23 , DOI: 10.1016/j.bbamcr.2020.118746
Jeffrey L Barr 1 , Ellen M Unterwald 2
Affiliation  

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase implicated in numerous physiological processes and cellular functions through its ability to regulate the function of many proteins, including transcription factors and structural proteins. GSK-3β has been demonstrated to function as a regulator of multiple behavioral processes induced by drugs of abuse, particularly psychostimulant drugs. In this review, we provide an overview of the regulation of GSK-3β activity produced by psychostimulants, and the role of GSK-3β signaling in psychostimulant-induced behaviors including drug reward, associative learning and memory which play a role in the maintenance of drug-seeking. Evidence supports the conclusion that GSK-3β is an important component of the actions of psychostimulant drugs and that GSK-3β is a valid target for developing novel therapeutics. Additional studies are required to examine the role of GSK-3β in distinct cell types within the mesolimbic and memory circuits to further elucidate the mechanisms related to the acquisition, consolidation, and recall of drug-related memories, and potentially countering neuroadaptations that reinforce drug-seeking behaviors that maintain drug dependence.



中文翻译:

糖原合酶激酶 3 信号在对精神兴奋剂药物的细胞和行为反应中。

糖原合酶激酶-3 (GSK-3) 是一种丝氨酸/苏氨酸激酶,通过其调节许多蛋白质(包括转录因子和结构蛋白)的功能的能力参与了许多生理过程和细胞功能。GSK-3β 已被证明可作为由滥用药物,特别是精神兴奋剂引起的多种行为过程的调节剂。在这篇综述中,我们概述了精神兴奋剂产生的 GSK-3β 活性的调节,以及 GSK-3β 信号在精神兴奋剂诱导的行为中的作用,包括药物奖励、联想学习和记忆,这些行为在维持药物作用中发挥作用。 - 寻求。证据支持以下结论:GSK-3β 是精神兴奋剂作用的重要组成部分,并且 GSK-3β 是开发新疗法的有效靶点。需要额外的研究来检查 GSK-3β 在中脑边缘和记忆回路中不同细胞类型中的作用,以进一步阐明与药物相关记忆的获取、巩固和回忆相关的机制,并可能对抗增强药物的神经适应。寻求维持药物依赖的行为。

更新日期:2020-05-23
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