Seaweeds can generate changes in metabolism of lipids and consequently diminish cholesterol and other serum lipids in mammals. However, the consumption of marine algae may also alter function of other organs. Therefore, the aim of this research was to study the metabolism of lipids as well as the liver steatosis of Wistar male rats fed for two months with hyperlipidic diets composed of 20% of fat supplemented with 2.5% of seaweeds Ecklonia arborea or Silvetia compressa. Blood total cholesterol, lipoproteins, triglycerides and key hepatic enzymes were determined and liver histologies were also assessed. The two algae produced different results, while S. compressa reduced 18% total cholesterol, E. arborea increased it 5.8% compared to the animals fed the positive control. Rats fed the S. compressa supplemented diet comparatively had lower serum low density lipoproteins (54%) and triglycerides (69%) levels compared to counterparts fed the high-fat diet. Livers histologies of rats fed with the high-fat diets showed an evident lipid accumulation. However, the consumption of S. compressa diminished liver steatosis compared to E. arborea. Results herein indicate that S. compressa is a promising resource to decrease serum total cholesterol and low-density lipoproteins and hepatic tissue damage. Further investigations should be made to find out if the ingestion of marine algae extracts would decrease the accumulation of hepatic fat and consequently affects positively liver physiology.

海藻可以改变脂质的代谢，从而减少哺乳动物的胆固醇和其他血清脂质。但是，食用海藻也可能会改变其他器官的功能。因此，本研究的目的是研究以高脂饮食喂养两个月的Wistar雄性大鼠的脂质代谢以及肝脂肪变性，该饮食由20％的脂肪和2.5％的海藻Ecklonia arborea或Silvetia compressa组成。测定了血液中的总胆固醇，脂蛋白，甘油三酸酯和主要的肝酶，并评估了肝脏组织学。两种藻类产生不同的结果，而压缩链球菌降低了总胆固醇18％的大肠杆菌与饲喂阳性对照的动物相比，它增加了5.8％。饲喂压缩链球菌饮食的大鼠与饲喂高脂饮食的大鼠相比，血清低密度脂蛋白（54％）和甘油三酸酯（69％）含量较低。用高脂饮食喂养的大鼠的肝脏组织学表现出明显的脂质蓄积。然而，压缩食用链球菌的食用量要比木本菌减少。本文的结果表明，S.compressa是减少血清总胆固醇和低密度脂蛋白和肝组织损伤的有前途的资源。应进行进一步调查，以了解摄入海藻提取物是否会减少肝脂肪的积累，从而对肝脏生理产生积极影响。