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Isolation of Bordetella trematum from the respiratory tract of a patient with lung cancer: a case report.
Folia Microbiologica ( IF 2.6 ) Pub Date : 2020-03-18 , DOI: 10.1007/s12223-020-00784-7
Rudolf Kukla 1 , Michal Svarc 2 , Radka Bolehovska 1 , Lenka Ryskova 1 , Pavla Paterova 1 , Miroslav Fajfr 1 , Lucia Malisova 3 , Helena Zemlickova 1, 3
Affiliation  

We report the case of isolation of Bordetella trematum from the respiratory tract of a patient with lung carcinoma. This gram-negative, opportunistic rod was firstly described in 1996. To date, only several strains of Bordetella trematum have been isolated and reported, mostly from skin and soft tissue infections. The patient was admitted to the ICU of the Pulmonary Department in incipient septic shock with respiratory failure. Intravenous fluid resuscitation and non-invasive ventilation were administered immediately. A broad spectrum antibiotic piperacillin/tazobactam was administered empirically after sampling of material for microbiological examination. The bronchoscopy showed a large cavern of decayed tumour invading into mediastinum. Both sample cultures showed significant quantities of gram-negative non-fermenting bacteria. The isolate was identified using MALDI-TOF MS as Bordetella trematum and the identification was confirmed using 16S ribosomal RNA sequencing. In the last few years, routine bacterial identification using MALDI-TOF MS has enabled correct discrimination of this species. Nevertheless, isolation of Bordetella trematum in clinical samples is still very uncommon, and it is appropriate to confirm the species identification via 16S ribosomal RNA sequencing. To our knowledge, this is the first case of B. trematum isolated from the human respiratory tract since its first description. The clinical significance of Bordetella trematum in the rapid deterioration of the patient's status remains unclear.

中文翻译:

从肺癌患者呼吸道中分离出博德特氏菌:一个病例报告。

我们报告了从肺癌患者的呼吸道分离出博德特氏菌的情况。这种革兰氏阴性的机会杆于1996年首次被描述。迄今为止,仅分离和报道了几种特级博德特氏菌博德特氏菌,主要来自皮肤和软组织感染。该患者因感染性初期休克伴呼吸衰竭而被送入肺部ICU。立即进行静脉液体复苏和无创通气。在对用于微生物学检查的材料进行采样后,凭经验施用广谱抗生素哌拉西林/他唑巴坦。支气管镜检查发现一个大的肿瘤浸润纵隔的洞穴。两种样品培养物均显示出大量的革兰氏阴性非发酵菌。使用MALDI-TOF MS鉴定了分离物为三叶博德特氏菌,并使用16S核糖体RNA测序确认了该鉴定。在过去的几年中,使用MALDI-TOF MS进行常规细菌鉴定已经能够正确区分该物种。尽管如此,在临床样品中分离博德特氏菌仍然很不常见,因此通过16S核糖体RNA测序确认物种鉴定是适当的。据我们所知,这是自人类呼吸道感染以来首次分离出的银发芽孢杆菌。在患者状态的快速恶化中,三叶博德氏杆菌的临床意义尚不清楚。使用MALDI-TOF MS进行常规细菌鉴定,可以正确区分该菌种。尽管如此,在临床样品中分离博德特氏菌仍然很不常见,因此通过16S核糖体RNA测序确认物种鉴定是适当的。据我们所知,这是自人类呼吸道感染以来首次分离出的银发芽孢杆菌。在患者状态的快速恶化中,三叶博德氏杆菌的临床意义尚不清楚。使用MALDI-TOF MS进行常规细菌鉴定,可以正确区分该菌种。尽管如此,在临床样品中分离出博德特氏菌还是很不常见的,通过16S核糖体RNA测序确认物种鉴定是适当的。据我们所知,这是自人类呼吸道感染以来首次分离出的银发芽孢杆菌。在患者状态的快速恶化中,三叶博德氏杆菌的临床意义尚不清楚。自从首次描述以来,这是第一例从人类呼吸道分离出的银发芽孢杆菌。在患者状态的快速恶化中,三叶博德氏杆菌的临床意义尚不清楚。自从首次描述以来,这是第一例从人类呼吸道分离出的银发芽孢杆菌。在患者状态的快速恶化中,三叶博德氏杆菌的临床意义尚不清楚。
更新日期:2020-03-18
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