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On-Chip Impedance for Quantifying Parasitic Voltages During AC Electrokinetic Trapping
IEEE Transactions on Biomedical Engineering ( IF 4.6 ) Pub Date : 2020-06-01 , DOI: 10.1109/tbme.2019.2942572
Vahid Farmehini , Walter Varhue , Armita Salahi , Alexandra R. Hyler , Jaka Cemazar , Rafael V. Davalos , Nathan S. Swami

Objective: Assessing the effectiveness of microfluidic device structures for enabling electrokinetic or acoustic trapping requires imaging of model particles within each device under the requisite force fields. To avoid the need for extensive microscopy, the use of valuable biological samples, and reliance on a trained operator to assess efficacy of trapping, we explore electrical means to identify device geometry variations that are responsible for the poor trapping. Results: Using the example of AC electrokinetic trapping over an insulated channel in a contact-less dielectrophoresis mode, we present an on-chip method to acquire impedance spectra on the microfluidic device for quantifying the parasitic voltage drops. Conclusion: Based on the parasitic voltage drops, device geometries can be designed to maximize fraction of the applied voltage that is available for dielectrophoretic manipulation and the measured on-chip impedance can rapidly inform downstream decisions on particle manipulation.

中文翻译:

用于量化交流电动捕获期间寄生电压的片上阻抗

目标:评估微流体装置结构实现电动或声学捕获的有效性需要在必要的力场下对每个装置内的模型粒子进行成像。为了避免需要大量显微镜检查、使用有价值的生物样本以及依赖训练有素的操作员来评估诱捕效果,我们探索了电气方法来识别导致诱捕不良的设备几何变化。结果:以非接触介电泳模式下绝缘通道上的交流电动势捕获为例,我们提出了一种在微流体装置上获取阻抗谱的片上方法,用于量化寄生电压降。结论:基于寄生电压降,
更新日期:2020-06-01
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