Cornea, an outermost layer of mammalian eye, is protected by tear film and abnormalities of tear film causes dry eye. Dry eye injures the cornea which results lower vision in patients. Several factors cause dry eye, including altered systemic conditions, environment, and immunological abnormality of the patient in autoimmune disease like Sjögren's syndrome (SS). However, the detailed pathology of autoimmune abnormality-mediated dry eye is unclear. Here we demonstrated that systemic autoimmune abnormality in BXSB-Yaa mice was associated with histological changes in the exocrine glands and cornea of the eyes. We also showed that BXSB-Yaa mice developed mild or early stage dry eye-like disease and explain the existence of a compensatory mechanism associated with the dysfunction of these tissues. Thus, BXSB-Yaa could be a model for SS-like disease-associated dry eye and these data would contribute to the understanding of the pathogenesis of autoimmune-related dry eye disease.

中文翻译：

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自身免疫性疾病小鼠模型中泪液分泌组织和角膜的组织病理学变化。

角膜是哺乳动物眼的最外层，受到泪膜的保护，而泪膜的异常会导致干眼症。干眼会损伤角膜，导致患者视力下降。引起干眼症的因素有很多，包括系统性疾病，环境的改变以及患者自身免疫性疾病（如干燥综合征）的免疫异常。但是，自身免疫异常介导的干眼的详细病理还不清楚。在这里，我们证明了BXSB-Yaa小鼠的全身性自身免疫异常与外分泌腺和眼角膜的组织学变化有关。我们还显示，BXSB-Yaa小鼠发展为轻度或早期干眼样疾病，并解释了与这些组织功能障碍相关的补偿机制的存在。从而，