Abstract

Ischemia/reperfusion injury is a complex molecular cascade that causes deleterious cellular damage and organ dysfunction. Stroke, sudden cardiac arrest, and acute myocardial infarction are the most common causes of ischemia/reperfusion injury without effective pharmacologic therapies. Existing preclinical evidence suggests that histone deacetylase inhibitors may be an efficacious, affordable, and clinically feasible therapy that can improve neurologic and cardiac outcomes following ischemia/reperfusion injury. In this review, we discuss the pathophysiology and epigenetic modulations of ischemia/reperfusion injury and focus on the neuroprotective and cardioprotective effects of histone deacetylase inhibitors. We also summarize the protective effects of histone deacetylase inhibitors for other vital organs and highlight the key research priorities for their successful translation to the bedside.

中文翻译：

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组蛋白脱乙酰基酶抑制剂：缺血/再灌注损伤后神经保护和心脏保护的新策略。

摘要

缺血/再灌注损伤是一个复杂的分子级联反应，会导致有害的细胞损伤和器官功能障碍。没有有效药理疗法，中风，心脏骤停和急性心肌梗塞是缺血/再灌注损伤的最常见原因。现有的临床前证据表明，组蛋白脱乙酰基酶抑制剂可能是一种有效，可负担且临床上可行的疗法，可改善缺血/再灌注损伤后的神经和心脏预后。在这篇综述中，我们讨论了缺血/再灌注损伤的病理生理学和表观遗传学调控，并着重研究了其的神经保护和心脏保护作用。组蛋白脱乙酰基酶抑制剂。我们还总结了保护作用组蛋白脱乙酰基酶抑制剂 其他重要器官，并着重指出将其成功翻译到床边的关键研究重点。