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Analyzing the impact of SARS CoV-2 on the human proteome
bioRxiv - Systems Biology Pub Date : 2020-05-21 , DOI: 10.1101/2020.05.21.107912
Ernesto Estrada

The COVID-19 respiratory disease is caused by the novel coronavirus SARS-CoV-2, which uses the enzyme ACE2 to entry human cells. This disease is characterized by important damages at multi-organ level, partially due to the abundant expression of ACE2 in practically all human tissues. However, not every organ in which ACE2 is abundant is affected by SARS CoV-2, which suggests the existence of other multi-organ routes for transmitting the perturbations produced by the virus. We consider here diffusive processes through the protein-protein interaction (PPI) network of proteins targeted by SARS CoV-2 as such alternative route. We found a subdiffusive regime that allows the propagation of virus perturbations through the PPI network at a significant rate. By following the main subdiffusive routes across the PPI network we identify proteins mainly expressed in the heart, cerebral cortex, thymus, testis, lymph node, kidney, among others of the organs reported to be affected by COVID-19.

中文翻译:

分析SARS CoV-2对人类蛋白质组的影响

COVID-19呼吸系统疾病是由新型冠状病毒SARS-CoV-2引起的,该病毒使用ACE2酶进入人体细胞。该疾病的特征在于多器官水平的重要损害,部分归因于几乎所有人体组织中ACE2的大量表达。但是,并非每个ACE2丰富的器官都受到SARS CoV-2的影响,这表明存在其他多器官途径来传播病毒产生的扰动。我们在这里考虑通过SARS CoV-2靶向的蛋白质的蛋白质-蛋白质相互作用(PPI)网络作为这种替代途径的扩散过程。我们发现了一个亚扩散机制,该机制允许病毒扰动以很高的速率通过PPI网络传播。
更新日期:2020-05-21
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