Abstract

Several natural products have been reported to be involved in the suppression of adipogenesis. In this study, we reveal that a bergamot extract (BE) decreased the accumulation of intracellular lipids in murine pre-adipocytes 3T3-L1 cells during adipogenic differentiation. Both the inhibition of HMG-CoA reductase activity and the differentiation and proliferation of adipocytes could be used as a strategy for the treatment and prevention of obesity. The results of this study show a reduction of HMG-CoA activity and of lipid droplet accumulation in the presence of the BE, suggesting the potential of BE as an anti-adipogenic agent to lower the content of cholesterol and body fat and prevent a gain in body weight. Moreover, BE as the result of high percentages of flavonoid compounds such as neoriocitrin, naringin and neohesperidin, the main flavonoids contained in BE, led to significant inhibition of DPPH free radical, demonstrating a strong radical scavenging activity.

摘要

据报道，几种天然产物参与抑制脂肪生成。在这项研究中，我们揭示了佛手柑提取物 (BE) 在成脂分化过程中减少了鼠前脂肪细胞 3T3-L1 细胞中细胞内脂质的积累。HMG-CoA 还原酶活性的抑制和脂肪细胞的分化和增殖均可用作治疗和预防肥胖症的策略。这项研究的结果表明，在 BE 存在下 HMG-CoA 活性和脂滴积累减少，表明 BE 作为抗脂肪生成剂降低胆固醇和体脂含量并防止脂肪增加的潜力体重。此外，由于高百分比的黄酮类化合物如新草次苷、柚皮苷和新橙皮苷导致 BE，