Abstract

Two new, aramatosides A and B (1 and 2), together with seven known oleanane-type triterpene saponins (3–9) were isolated from the leaves of Aralia armata. Their structures were determined by combination of HR-ESI-MS, 1 D and 2 D NMR spectral data as well as comparison with the previous literature. Compounds 6–9 exhibited cytotoxic effects towards three human cancer cell lines (HT29, A2058, and A549) with IC₅₀ values ranging from 2.01 ± 0.17 to 18.8 ± 1.17 µM. Especially, compound 7 (narcissiflorin) showed significant cytotoxic activity against HT29 and A549 cell lines with IC₅₀ values of 2.02 ± 1.65 and 2.01 ± 0.17 µM, respectively, which are smaller than those of positive control irinotecan hydrochloride (IC₅₀ values of 10.3 ± 1.32 and 9.89 ± 0.19 µM).

摘要

两个新的，aramatosides A和B（1和2），用七已知齐墩果烷型三萜皂甙（一起3 - 9）从叶中分离龙牙ARMATA。它们的结构是通过结合 HR-ESI-MS、1 D 和 2 D NMR 光谱数据以及与以前的文献进行比较来确定的。化合物6 – 9对三种人类癌细胞系（HT29、A2058 和 A549）表现出细胞毒性作用，IC ₅₀值范围为 2.01 ± 0.17 至 18.8 ± 1.17 µM。特别是，化合物7（水仙花素）对 HT29 和 A549 细胞系显示出显着的细胞毒活性，IC ₅₀值分别为 2.02 ± 1.65 和 2.01 ± 0.17 µM，小于阳性对照盐酸伊立替康（IC ₅₀值为 10.3 ± 1.32 和 9.89 ± 0.19 µM）。