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[6]-Gingerol Ameliorates ISO-Induced Myocardial Fibrosis by Reducing Oxidative Stress, Inflammation, and Apoptosis through Inhibition of TLR4/MAPKs/NF-κB Pathway.
Molecular Nutrition & Food Research ( IF 5.2 ) Pub Date : 2020-06-08 , DOI: 10.1002/mnfr.202000003
Xue Han 1, 2 , Panpan Liu 1 , Miaomiao Liu 1 , Ziheng Wei 1 , Sen Fan 3 , Xiangting Wang 4, 5 , Shijiang Sun 6 , Li Chu 1, 4
Affiliation  

[6]‐Gingerol is one of the primary pungent constituents of ginger. While [6]‐gingerol has many pharmacological effects, its benefits for myocardial fibrosis, including its exact role and underlying mechanisms, remain largely unexplored. The present study is designed to characterize the cardio‐protective effects of [6]‐gingerol in myocardial fibrosis mice and possible underlying mechanisms.

中文翻译:

[6]-姜油通过抑制TLR4 / MAPKs /NF-κB途径来减少氧化应激,炎症和细胞凋亡,从而减轻了ISO诱导的心肌纤维化。

[6]-姜油是姜的主要刺激性成分之一。尽管[6]-姜油醇具有许多药理作用,但它对心肌纤维化的益处,包括其确切的作用和潜在的机制,在很大程度上仍未得到开发。本研究旨在表征[6]-姜油醇对心肌纤维化小鼠的心脏保护作用及其可能的潜在机制。
更新日期:2020-06-08
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