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The caudal neurosecretory system: A novel thermosensitive tissue and its signal pathway in olive flounder (Paralichthys olivaceus).
Journal of Neuroendocrinology ( IF 3.2 ) Pub Date : 2020-05-22 , DOI: 10.1111/jne.12876
Mingzhe Yuan 1, 2, 3 , Xiaoxue Li 1, 2, 3 , Weiqun Lu 1, 2, 3
Affiliation  

Ectotherm animals, such as fish, are vulnerable when facing an extreme temperature fluctuation as a result of their inability to maintain body temperature. The caudal neurosecretory system (CNSS) is unique to fish and has been shown to maintain homeostasis in response to seasonal changes. However, its temperature sensitivity is unknown. Here, we used in vitro electrophysiological and anatomical approaches to investigate a thermosensory pathway in the CNSS. We showed that the CNSS responds directly to local hypothermal challenge via the TRP channel, and transmits this signal using the neurotransmitter, GABA, to the neurosecretory Dahlgren cells of the CNSS. These findings are the first demonstration of the thermal perception of the CNSS and add to our understanding of the physiological role of the CNSS in thermoregulation and seasonal adaptation.

中文翻译:

尾神经分泌系统:一种新型的热敏感组织及其在橄榄比目鱼(Paralichthys olivaceus)中的信号通路。

由于动物无法维持体温,因此在面对极端温度波动时,诸如鱼类等外来动物很容易受到伤害。尾神经分泌系统(CNSS)对于鱼类而言是独特的,并且已经显示出可以响应季节变化而保持体内平衡。但是,其温度敏感性未知。在这里,我们使用了体外电生理学和解剖学方法来研究CNSS中的热感通路。我们表明,CNSS通过TRP通道直接响应局部低温挑战,并使用神经递质GABA将该信号传递至CNSS的神经分泌Dahlgren细胞。这些发现是对CNSS热感知的首次证明,并加深了我们对CNSS在温度调节和季节适应中的生理作用的理解。
更新日期:2020-06-23
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