Abstract Hyperglycemia, hyperlipidemia, and oxidative stress are an important pathological conditions in diabetes which are linked with the progression of diabetic cardiomyopathy. Cardiomyopathy is considered as one of the major cause of mortality in diabetic patients. The present study focuses on the effect of Bauhinia variegata Linn leaves in the management of diabetic cardiomyopathy. Alcoholic extract of Bauhinia variegata Linn leaves (AlcE) was prepared and standardized using liquid chromatography-mass spectroscopy (LC-MS) analysis. Male Sprague Dawley rats received a single intraperitoneal injection of streptozotocin (55 mg/kg) for induction of diabetes. After 6 weeks of diabetes induction, animals were treated with AlcE at the dose of 250, 500 and 1000 mg/kg by oral route for next 28 days. Diabetic control animals showed a significant increased level of blood glucose (P Form the results, it can be concluded that Bauhinia variegata extract is having significant effect in the management of diabetic cardiomyopathy.

中文翻译：

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紫荆叶提取物：糖尿病心肌病的有效管理选择

摘要 高血糖、高脂血症和氧化应激是糖尿病的重要病理状态，与糖尿病心肌病的进展密切相关。心肌病被认为是糖尿病患者死亡的主要原因之一。本研究的重点是紫荆叶在糖尿病心肌病治疗中的作用。使用液相色谱-质谱 (LC-MS) 分析制备和标准化紫荆叶 (AlcE) 的酒精提取物。雄性 Sprague Dawley 大鼠接受单次腹膜内注射链脲佐菌素 (55 mg/kg) 以诱发糖尿病。糖尿病诱导 6 周后，在接下来的 28 天内，通过口服途径以 250、500 和 1000 mg/kg 的剂量用 AlcE 治疗动物。