Rearrangements are discrete processes whereby discrete segments of DNA are deleted, replicated and inserted into novel positions. A sequence of such configurations, termed a rearrangement evolution, results in jumbled DNA arrangements, frequently observed in cancer genomes. We introduce a method that allows us to precisely count these different evolutions for a range of processes including breakage-fusion-bridge-cycles, tandem-duplications, inverted-duplications, reversals, transpositions and deletions, showing that the space of rearrangement evolution is super-exponential in size. These counts assume the infinite sites model of unique breakpoint usage.

中文翻译：

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无限位点模型下基因组重排组合的复杂性。

重排是离散的过程，其中DNA的离散片段被删除，复制并插入到新的位置。这种配置的序列称为重排进化，导致混乱的DNA排列，经常在癌症基因组中观察到。我们介绍了一种方法，可以使我们精确地计算出一系列不同过程的不同进化，包括断裂-融合-桥环循环，串联重复，反向重复，逆转，转座和缺失，这表明重排进化的空间是超-大小指数。这些计数假设使用唯一断点的无限站点模型。