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Serum oxytocin concentrations in current and recent suicide survivors are lower than in healthy controls.
Journal of Psychiatric Research ( IF 4.8 ) Pub Date : 2020-05-22 , DOI: 10.1016/j.jpsychires.2020.05.014
Leila Jahangard 1 , Mehran Shayganfard 2 , Farahnaz Ghiasi 1 , Iraj Salehi 1 , Mohammad Haghighi 1 , Mohammad Ahmadpanah 1 , Dena Sadeghi Bahmani 3 , Serge Brand 4
Affiliation  

Background

Suicide and suicide attempts are dramatic events both for the individuals concerned and for their social circles. From a psychopathological perspective, suicidal behavior could be understood as a severe breakdown in relations with their social worlds. Oxytocin is a neuropeptide highly involved in the perception of facets of social relationship such as their quality feelings of belongingness, and mutual trust. Given this, we expected that serum oxytocin concentrations would be lower in current and recent suicide survivors than in healthy controls.

Methods

A total of 48 participants (mean age: 27 years; 62.5% females) took part in the study. Of these, 16 (62.5% females) survived a suicide attempt 12–24 h ago; 16 (62.5% females) had made a suicide attempt about 12 weeks ago, and 16 (62.5% females) were healthy age- and gender-matched controls. Blood samples were taken in the morning to assess serum oxytocin concentrations. Participants also completed questionnaires covering sociodemographic information and a scale assessing suicidal ideation.

Results

Compared to healthy controls, suicide survivors had significantly lower serum oxytocin concentrations, but these levels did not differ between current and recent suicide survivors. Compared to healthy controls and recent suicide attempters, current suicide attempters recorded significantly higher scores on the Beck scale for suicidal ideation. Across the sample as a whole, higher scores for suicidal ideation were associated with lower serum oxytocin concentrations. Serum oxytocin concentrations and scores on the Beck scale for suicidal ideation did not differ between females and males.

Conclusions

Given that oxytocin is a neurobiological correlate of subjectively perceived quality of social interaction and social relationships, the results support the notion that suicide attempts are closely linked to suicide survivors' perceptions of the quality of their social lives. Speculatively, and based on the serum oxytocin concentrations, it also appears that 12 weeks after a suicide attempt, the survivor's perceived quality of social life has not significantly improved.



中文翻译:

目前和最近的自杀幸存者中的血清催产素浓度低于健康人。

背景

自杀和自杀企图对于有关个人及其社会圈子都是戏剧性的事件。从心理病理学的角度来看,自杀行为可以理解为与他们的社会世界的关系的严重崩溃。催产素是一种神经肽,高度参与社会关系各个方面的感知,例如他们对归属感的良好感觉和相互信任。鉴于此,我们预计目前和最近的自杀幸存者的血清催产素浓度将低于健康对照者。

方法

共有48位参与者(平均年龄:27岁; 62.5%的女性)参加了该研究。其中,有16名(62.5%的女性)在12-24小时前未曾自杀过。16名(62.5%的女性)在大约12周前曾尝试过自杀,而16名(62.5%的女性)是年龄和性别相匹配的健康对照。早晨采集血样以评估血清催产素浓度。参加者还完成了有关社会人口统计学信息的问卷以及评估自杀意念的量表。

结果

与健康对照组相比,自杀幸存者的血清催产素浓度明显降低,但是目前和最近的自杀幸存者之间的这些水平没有差异。与健康对照和最近的自杀未遂相比,当前自杀未遂在Beck量表上记录的自杀意念得分明显更高。在整个样本中,自杀意念得分较高与血清催产素浓度较低有关。男女之间的血清催产素浓度和贝克意念自杀评分没有差异。

结论

鉴于催产素是主观感觉到的社会互动和社会关系质量的神经生物学关联,结果支持自杀未遂与自杀幸存者对其社交生活质量的看法紧密相关的观点。根据血清催产素浓度推测,自杀未遂12周后,幸存者的社交生活质量并未得到明显改善。

更新日期:2020-05-22
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