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CRISPR-Cas9 system: A genome-editing tool with endless possibilities.
Journal of Biotechnology ( IF 4.1 ) Pub Date : 2020-05-22 , DOI: 10.1016/j.jbiotec.2020.05.008
Swati Tyagi 1 , Robin Kumar 2 , Aparup Das 3 , So Youn Won 1 , Pratyoosh Shukla 4
Affiliation  

The discovery of CRISPR: Cas9 and its application as a powerful gene-editing tool has transformed the world of basic and applied science, especially the molecular biology dome. Also, the smooth, quick, flexible, and very efficient nature of this technology has enabled the biologists to alter the genome of prokaryotes to complex eukaryotic systems, including plants and animals. Using CRISPR and associated tools, investigation, control, and modification of significant biological events have been more accessible than before. These biological scissors are now being used to accelerate breeding programs of crop and livestock, engineer new antimicrobials, and control disease-carrying pathogens. However, like other techniques, these cutters emerged as a double-edged sword and put several challenges to the scientific society. Here in this review article, we summarized the beneficial application of the CRISPR: Cas9 system and unsafe perception to the society if handled carelessly. We also discussed the limitations and ethical issues related to CRISPR: Cas9 technology.



中文翻译:

CRISPR-Cas9系统:一种具有无限可能性的基因组编辑工具。

CRISPR:Cas9的发现及其作为强大的基因编辑工具的应用已经改变了基础科学和应用科学的世界,尤其是分子生物学领域。而且,该技术的平稳,快速,灵活和非常有效的性质使生物学家能够将原核生物的基因组改变为复杂的真核生物系统,包括动植物。使用CRISPR和相关工具,对重大生物学事件的研究,控制和修饰比以前更容易获得。这些生物剪刀现已用于加速农作物和牲畜的育种程序,设计新的抗菌剂并控制携带疾病的病原体。但是,与其他技术一样,这些刀具成为一把双刃剑,对科学社会提出了一些挑战。在这篇评论文章中,我们总结了CRISPR:Cas9系统的有益应用以及如果不小心处理会给社会带来不安全感。我们还讨论了与CRISPR:Cas9技术相关的局限性和道德问题。

更新日期:2020-05-22
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