To-date, there has not been a clear signal suggesting that asthma or treatment with inhaled steroids are a risk factor for severe COVID-19 disease. We have therefore explored ACE2 receptor mRNA expression, and co-factors for Sars-CoV-2 infectivity (TMPRSS2 and furin) in bronchial brushes and biopsies from people with asthma and healthy controls, and looked for relationships between asthma severity, Th2- and IL-17 dependent gene signatures, and clinical demographics (age, sex). We have looked at a cohort of 356 research participants from previously described studies. The only significant association was a positive correlation between ACE2 and IL-17-dependent gene expression, and an inverse correlation between ACE2 and Th2-cytokine-dependent gene expression. These data suggest that differences in ACE2, TMPRSS2 and furin epithelial and airway gene expression are unlikely to confer enhanced COVID-19 pneumonia risk in patients with asthma across all treatment intensities and severity.

迄今为止，尚无明确信号表明哮喘或吸入类固醇激素治疗是严重COVID-19疾病的危险因素。因此，我们研究了哮喘和健康对照者的支气管刷和活检组织中ACE2受体mRNA表达以及Sars-CoV-2感染性的辅助因子（TMPRSS2和弗林蛋白酶），并探讨了哮喘严重程度，Th2-和IL之间的关系-17个依赖性基因签名，以及临床人口统计信息（年龄，性别）。我们从先前描述的研究中选出了356位研究参与者。唯一显着的关联是ACE2和IL-17依赖性基因表达之间呈正相关，而ACE2和Th2细胞因子依赖性基因表达之间呈负相关。这些数据表明ACE2，