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Sex Differences in Internalizing Symptoms and Amygdala Functional Connectivity in Neurotypical Youth.
Developmental Cognitive Neuroscience ( IF 4.7 ) Pub Date : 2020-05-22 , DOI: 10.1016/j.dcn.2020.100797
N T Padgaonkar 1 , K E Lawrence 1 , L M Hernandez 1 , S A Green 1 , A Galván 1 , M Dapretto 1
Affiliation  

Amygdala resting-state functional connectivity (rsFC) is altered in adolescents with internalizing disorders, though the relationship between rsFC and subclinical symptomatology in neurotypical youth remains unclear. Here we examined whether amygdala rsFC varied across a continuum of internalizing symptoms in 110 typically-developing (TD) youths 8 to 17 years old using functional magnetic resonance imaging (fMRI). We assessed overall internalizing symptoms, as well as anxious-depressed, withdrawn-depressed, and somatic complaints. Given known sex differences in the prevalence of internalizing disorders, we compared connectivity between males and females. As compared to males, females with greater internalizing, anxious-depressed, and somatic symptoms displayed greater connectivity with the cingulate gyrus, insula, and somatosensory cortices. In contrast, males with greater anxious-depressed symptoms demonstrated weaker connectivity with the subcallosal prefrontal cortex. Sex differences in rsFC in relation to symptom severity were evident for the whole amygdala and for two of its subnuclei (centromedial and superficial amygdala). Overall, results suggest that, for females, higher internalizing symptoms are associated with greater rsFC between the amygdala and regions implicated in emotional and somatosensory processing, salience detection, and action selection. Future longitudinal investigations are needed to determine whether this hyperconnectivity may confer resilience to, or pose risk for, the development of internalizing disorders.



中文翻译:

神经性青年中内在症状和杏仁核功能连接的性别差异。

在具有内在性疾病的青少年中,杏仁核的静息状态功能连接性(rsFC)发生了改变,尽管在神经型青年中rsFC与亚临床症状之间的关系尚不清楚。在这里,我们使用功能磁共振成像(fMRI)检查了110例8至17岁的典型发展中(TD)青年中杏仁核rsFC是否在一系列内在症状内变化。我们评估了整体的内在症状,以及焦虑抑郁,撤消抑郁和躯体不适。考虑到内化障碍患病率的已知性别差异,我们比较了男性和女性之间的连通性。与雄性相比,雌性具有更强的内在化,焦虑抑郁和躯体症状,它们与扣带回,岛突和体感皮质的连通性更高。相比之下,焦虑抑郁症状更严重的男性表现出与call下前额叶皮层的连通性较弱。对于整个杏仁核及其两个亚核(中央和浅杏仁核),rsFC的性别差异均与症状严重程度有关。总体而言,结果表明,对于女性而言,较高的内在症状与杏仁核和涉及情感和体感处理,显着性检测和行动选择的区域之间的rsFC较高有关。需要进行进一步的纵向调查,以确定这种过度连接是否可能赋予内在性疾病发展弹性或带来内在疾病的风险。对于整个杏仁核及其两个亚核(中央和浅杏仁核),rsFC的性别差异均与症状严重程度有关。总体而言,结果表明,对于女性而言,较高的内在症状与杏仁核和涉及情感和体感处理,显着性检测和行动选择的区域之间的rsFC较高有关。需要进行进一步的纵向调查,以确定这种过度连接是否可能赋予内在性疾病发展弹性或带来内在疾病的风险。对于整个杏仁核及其两个亚核(中央和浅杏仁核),rsFC的性别差异均与症状严重程度有关。总体而言,结果表明,对于女性而言,较高的内在症状与杏仁核和涉及情感和体感处理,显着性检测和行动选择的区域之间的rsFC较高有关。需要进行进一步的纵向调查,以确定这种过度连接是否可能赋予内在性疾病发展弹性或带来内在疾病的风险。较高的内在症状与杏仁核和涉及情绪和体感处理,显着性检测和行动选择的区域之间的rsFC较高相关。需要进行进一步的纵向研究,以确定这种过度连接是否可能赋予内在性疾病发展弹性或带来内在疾病的风险。较高的内在症状与杏仁核和涉及情绪和体感处理,显着性检测和行动选择的区域之间的rsFC较高相关。需要进行进一步的纵向调查,以确定这种过度连接是否可能赋予内在性疾病发展弹性或带来内在疾病的风险。

更新日期:2020-05-22
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