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Reciprocal Influences of HIV and Cannabinoids on the Brain and Cognitive Function.
Journal of Neuroimmune Pharmacology ( IF 6.2 ) Pub Date : 2020-05-22 , DOI: 10.1007/s11481-020-09921-y
Sheri L Towe 1 , Christina S Meade 1 , Christine C Cloak 2 , Ryan P Bell 1 , Julian Baptiste 2 , Linda Chang 2, 3, 4
Affiliation  

Globally, cannabis is the most commonly used illicit drug, with disproportionately high use among persons with HIV. Despite advances in HIV care, nearly half of persons living with HIV continue to experience neurocognitive deficits or impairments that may have negative impacts on their daily function. Chronic cannabis use may play a role in the development or exacerbation of these impairments. Here we present a review summarizing existing research detailing the effect of cannabis use associated with the neuropathogenesis of HIV. We examine evidence for possible additive or synergistic effects of HIV infection and cannabis use on neuroHIV in both the preclinical and adult human literatures, including in vitro studies, animal models, clinical neuroimaging research, and studies examining the cognitive effects of cannabis. We discuss the limitations of existing research, including methodological challenges involved with clinical research with human subjects. We identify gaps in the field and propose critical research questions to advance our understanding of how cannabis use affects neuroHIV. Graphical Abstract.

中文翻译:

HIV 和大麻素对大脑和认知功能的相互影响。

在全球范围内,大麻是最常用的非法药物,在艾滋病毒感染者中吸食大麻的人数高得不成比例。尽管 HIV 护理取得了进步,但近一半的 HIV 感染者仍然存在神经认知缺陷或损伤,这可能对其日常功能产生负面影响。长期使用大麻可能在这些损伤的发展或恶化中发挥作用。在这里,我们发表了一篇综述,总结了现有研究,详细介绍了大麻使用与 HIV 神经发病机制相关的影响。我们在临床前和成人人类文献中检查了 HIV 感染和大麻使用对 neuroHIV 可能产生的累加或协同效应的证据,包括体外研究、动物模型、临床神经影像学研究和检查大麻认知影响的研究。我们讨论了现有研究的局限性,包括涉及人类受试者临床研究的方法学挑战。我们找出该领域的差距并提出关键的研究问题,以增进我们对大麻使用如何影响 neuroHIV 的理解。图形概要。
更新日期:2020-05-22
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