In recent years, sustainable green chemistry sets eco-efficiency approaches to synthesis next generation nanomaterials using plant sources as reducing agents. Among them, reduced Graphene oxide (rGO) has been developing as biocompatible nanomaterials in biomedicine. The present work deals with facile synthesis of rGO using leaf extract of Lantana camara (LC). The bioreduction of graphene oxide (GO) to reduced Graphene oxide by L. camara (LCrGO) was confirmed by spectroscopic techniques such as UV–visible, XRD, FTIR, Raman spectrometer, Zeta potential and DLS. SEM and TEM microscopic revealed the presence of thin nano sheets of LCrGO. EDX detected intense signals of Carbon (86%) and Oxygen (13%) present in LCrGO. The bioreduced LCrGO showed potential in vitro biological effects. DPPH assay showed 79% radical inhibition at 500 µg/ml. The LCrGO exhibited enhanced bactericidal effects against B. subtilis (16 mm) and E. coli (12 mm) at 500 µg/ml. MTT assay showed concentration dependent cytotoxic effects against lung cancer cell lines (A549) with decrease in cell viability (44%) at maximum concentration of LCrGO (500 µg/ml). From the observations, it is concluded that rGO nanosheets synthesized using L. camara could be used for formulation of nanomedicine.

近年来，可持续的绿色化学为利用植物源作为还原剂合成下一代纳米材料设定了生态效率方法。其中，还原型氧化石墨烯（rGO）已被开发为生物医学中的生物相容性纳米材料。本工作涉及使用马樱丹（LC）的叶提取物轻松合成rGO 。卡马拉乳杆菌将氧化石墨烯（GO）还原为氧化石墨烯（LCrGO）已通过光谱技术证实，例如紫外可见光，XRD，FTIR，拉曼光谱仪，Zeta电位和DLS。SEM和TEM显微镜显示出LCrGO纳米薄片的存在。EDX检测到LCrGO中存在碳（86％）和氧（13％）的强烈信号。生物还原的LCrGO显示出潜在的体外生物学效应。DPPH测定显示500 µg / ml时有79％的自由基抑制作用。LCrGO对500 µg / ml的枯草芽孢杆菌（16 mm）和大肠杆菌（12 mm）表现出增强的杀菌作用。MTT分析显示在最大浓度的LCrGO（500 µg / ml）下，针对肺癌细胞系（A549）的浓度依赖性细胞毒性作用导致细胞活力下降（44％）。从观察结果可以得出结论，rGO纳米片是使用卡马拉乳杆菌可用于配制纳米药物。