Aim and Objective: Methyldopa is one of the medications that is used for the treatment of hypertension. Therefore, the determination of methyldopa in the presence of other biological components is essential. In this work, a promising electrochemical sensor based on CoFe₂O₄ magnetic nanoparticles modified glassy carbon electrode (CoFe₂O₄/GCE) was developed for electrochemical determination of methyldopa in the presence of uric acid. Cobalt ferrite nanoparticles were synthesized via chemical method.

Materials and Methods: Characterizing the CoFe₂O₄ was investigated by field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDX), transmission electron microscope (TEM), and cyclic voltammetry techniques.

Results: Under the optimal experimental conditions, the current response of the electrochemical sensor obtained with differential pulse voltammetry was increased linearly in the concentration range from 1.45 to 15.1 μmol L⁻¹ with the detection limit of 1.07 μmol L⁻¹ for methyldopa. Also, by using the proposed method, methyldopa and uric acid could be analyzed in a mixture independently. The difference in peak potential for analytes is about 150 mV.

Conclusion: The present sensor was successfully applied for the determination of methyldopa in the presence of uric acid in biological samples and the pharmaceutical samples with satisfactory results.

目的和目的：甲基多巴是用于治疗高血压的药物之一。因此，在其他生物成分存在下测定甲基多巴至关重要。在这项工作中，开发了一种有前途的基于CoFe ₂ O ₄磁性纳米粒子修饰的玻碳电极的电化学传感器（CoFe ₂ O ₄ / GCE），用于在尿酸存在下电化学测定甲基多巴。通过化学方法合成了铁氧体钴纳米颗粒。

材料和方法：通过场发射扫描电子显微镜（FESEM），X射线衍射（XRD），能量色散X射线光谱（EDX），透射电子显微镜（TEM）和循环伏安法研究了CoFe ₂ O _4的表征。技术。

结果：在最佳实验条件下，通过差分脉冲伏安法获得的电化学传感器的电流响应在1.45至15.1μmolL ^-1的浓度范围内线性增加，甲基多巴的检出限为1.07μmolL ^-1。同样，通过使用所提出的方法，可以独立地分析混合物中的甲基多巴和尿酸。分析物的峰值电势差约为150 mV。

结论：本传感器已成功用于生物样品和药物样品中尿酸存在下甲基多巴的测定，结果令人满意。