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Facile nano-free electrochemiluminescence biosensor for detection of sulphamethoxazole via tris(2,2'-bipyridyl)ruthenium(II) and N-methyl pyrrolidone recognition.
IET Nanobiotechnology ( IF 2.3 ) Pub Date : 2020-04-01 , DOI: 10.1049/iet-nbt.2019.0257
Xiyuan Tong 1 , Shiyao Jin 1 , Yingdai Zhao 1 , Yue Gai 1 , Yifeng E 1 , Dan Li 1
Affiliation  

The electrochemiluminescence (ECL) system based on the ruthenium complex has become a powerful tool in the field of analytical chemistry. However, the non-aqueous ECL luminescence system, which does not involve complex nano-modification, has not been widely used for the determination of analytes. In this study, N-methyl pyrrolidone was selected as the solvent, and it could also act as a co-reactant of [inline-formula removed]. Based on this, a simple ECL system without nanomaterials was established. Strong ECL was generated. Furthermore, a quenching effect between the excited state of [inline-formula removed] and sulphamethoxazole (SMZ) was observed. Based on this, a sensitive ECL sensor for detecting SMZ is constructed. A linear relationship between ECL signal quenching intensity (ΔI) and the logarithm of SMZ concentration (log C) in the concentration range of 1 × 10-7-1 × 10-5 mol/l is obtained. The limit of detection is as low as 3.33 × 10-9 mol/l. The method has been applied to the detection of SMZ in tap water samples with different concentration levels with satisfactory results, and the recovery was 95.3-102.6%.

中文翻译:

用于通过三(2,2'-联吡啶)钌(II)和 N-甲基吡咯烷酮识别检测磺胺甲恶唑的简便无纳米电化学发光生物传感器。

基于钌配合物的电化学发光(ECL)系统已成为分析化学领域的有力工具。然而,不涉及复杂纳米修饰的非水 ECL 发光系统尚未广泛用于分析物的测定。在本研究中,选择 N-甲基吡咯烷酮作为溶剂,它也可以作为 [inline-formula removed] 的共反应物。在此基础上,建立了一个简单的不含纳米材料的 ECL 系统。生成了强 ECL。此外,观察到[在线式去除]的激发态与磺胺甲恶唑 (SMZ) 之间的猝灭效应。在此基础上,构建了用于检测SMZ的灵敏ECL传感器。得到1×10-7-1×10-5 mol/l浓度范围内ECL信号猝灭强度(ΔI)与SMZ浓度对数(log C)的线性关系。检测限低至 3.33 × 10-9 mol/l。该方法已应用于不同浓度自来水样品中SMZ的检测,结果满意,回收率为95.3-102.6%。
更新日期:2020-04-01
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