Members of birth cohorts who were alive in 1918 and survived the influenza pandemic were likely to have been "primed" for heart disease in later life. We examine the hypothesis that the twentieth-century heart disease epidemic was a cohort effect reflecting the changing susceptibility composition of the population.We estimated heart disease death rates by single years of age for cohorts born in 1860-1949. We prepared age-specific rates for calendar years 1900-2016, as well as age-standardized cohort and calendar year rates.Males born in 1880-1919 contributed 90 per cent to 100 per cent of all heart disease deaths among males aged 40-64 from 1940 to 1959, when the heart disease epidemic was at its peak. There was no heart disease epidemic among females aged 40-64. Death from heart disease in females tends to occur at older ages.Cigarette smoking, unemployment, and other factors may have played a role in the heart disease epidemic in men and would have interacted with injury from influenza, but our results suggest that having been alive at the time of the 1918 influenza pandemic probably played an important role.

中文翻译：

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1918年的大流行和美国中年男女心脏病的流行。

在1918年还活着并在流感大流行中幸存下来的出生队列成员很可能在晚年因心脏病而“被引发”。我们检验了20世纪心脏病流行是反映人群易感性变化的队列效应这一假设。我们估算了1860-1949年出生的队列人群按年龄计算的心脏病死亡率。我们准备了1900-2016日历年的特定年龄比率以及年龄标准化的队列和日历年比率.1880-1919年出生的男性在40-64岁的男性中占所有心脏病死亡人数的90％至100％从1940年到1959年，当时心脏病的流行达到顶峰。40-64岁的女性中没有心脏病流行病。女性因心脏病死于年纪较大。