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Prealbumin: The clinical utility and analytical methodologies.
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine ( IF 2.2 ) Pub Date : 2020-06-11 , DOI: 10.1177/0004563220931885
Ruvini Nk Ranasinghe 1 , Milly Biswas 1 , Royce P Vincent 1
Affiliation  

Prealbumin is a small protein which has been widely evaluated as a nutritional and a prognostic marker. The small size and concentration of prealbumin in blood proposes challenges on measuring it with high sensitivity and specificity. Over the years, a number of analytical methodologies have been developed, which may help establish prealbumin as a useful biomarker in routine clinical practice. The aim of the short review was to explore the current literature on the clinical utility of prealbumin and the advances made in the analytical methodologies of prealbumin. We searched MEDLINE, EMBASE and the Cochrane Library for articles published between January 1980 and July 2019, with the general search terms of ‘prealbumin’, ‘prognostic marker’, ‘nutritional marker’, ‘analytical methodologies’ and ‘malnutrition’. Additionally, we selected relevant articles and comprehensive overviews from reference lists of identified studies. The routine use of prealbumin in clinical practice remains debatable; however; it can complement clinical history, anthropometric assessment and physical examination to assess malnutrition with more certainty. Consensus on the clinical applications of prealbumin in the management of malnutrition is warranted.



中文翻译:

前白蛋白:临床效用和分析方法。

前白蛋白是一种小蛋白,已被广泛评估为营养和预后标志物。血液中前白蛋白的小尺寸和浓度对以高灵敏度和特异性测量它提出了挑战。多年来,已经开发了许多分析方法,这可能有助于将前白蛋白确立为常规临床实践中有用的生物标志物。简短回顾的目的是探索当前关于前白蛋白临床效用的文献以及前白蛋白分析方法的进展。我们在 MEDLINE、EMBASE 和 Cochrane 图书馆中搜索了 1980 年 1 月至 2019 年 7 月期间发表的文章,一般搜索词为“前白蛋​​白”、“预后标记”、“营养标记”、“分析方法”和“营养不良”。此外,我们从已确定研究的参考列表中选择了相关文章和综合概述。临床实践中前白蛋白的常规使用仍有争议;然而; 它可以补充临床病史、人体测量学评估和体格检查,以更确定地评估营养不良。有必要就前白蛋白在营养不良管理中的临床应用达成共识。

更新日期:2020-06-30
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