当前位置: X-MOL 学术mBio › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Carboxylic Acid Transporters in Candida Pathogenesis.
mBio ( IF 6.4 ) Pub Date : 2020-05-12 , DOI: 10.1128/mbio.00156-20
Rosana Alves 1, 2 , Maria Sousa-Silva 1, 2 , Daniel Vieira 1, 2 , Pedro Soares 1, 2 , Yasmin Chebaro 3 , Michael C Lorenz 4 , Margarida Casal 1, 2 , Isabel Soares-Silva 1, 2 , Sandra Paiva 2, 5
Affiliation  

Opportunistic pathogens such as Candida species can use carboxylic acids, like acetate and lactate, to survive and successfully thrive in different environmental niches. These nonfermentable substrates are frequently the major carbon sources present in certain human body sites, and their efficient uptake by regulated plasma membrane transporters plays a critical role in such nutrient-limited conditions. Here, we cover the physiology and regulation of these proteins and their potential role in Candida virulence. This review also presents an evolutionary analysis of orthologues of the Saccharomyces cerevisiae Jen1 lactate and Ady2 acetate transporters, including a phylogenetic analysis of 101 putative carboxylate transporters in twelve medically relevant Candida species. These proteins are assigned to distinct clades according to their amino acid sequence homology and represent the major carboxylic acid uptake systems in yeast. While Jen transporters belong to the sialate:H+ symporter (SHS) family, the Ady2 homologue members are assigned to the acetate uptake transporter (AceTr) family. Here, we reclassify the later members as ATO (acetate transporter ortholog). The new nomenclature will facilitate the study of these transporters, as well as the analysis of their relevance for Candida pathogenesis.

中文翻译:

假丝酵母发病机理中的羧酸转运蛋白。

机会性病原体(例如念珠菌)可以使用羧酸(例如乙酸盐和乳酸盐)在不同的环境中生存并成功繁殖。这些不可发酵的底物通常是某些人体部位中存在的主要碳源,在这种营养受限的条件下,被调节的质膜转运蛋白有效吸收这些物质起着至关重要的作用。在这里,我们介绍了这些蛋白质的生理和调控及其在念珠菌毒力中的潜在作用。这篇综述还提出了酿酒酵母Jen1乳酸和Ady2乙酸转运蛋白的直向同源物的进化分析,包括在十二种医学上相关的101种假定的羧酸酯转运蛋白的系统发育分析。念珠菌种。这些蛋白质根据其氨基酸序列同源性分配给不同的进化枝,代表了酵母中主要的羧酸吸收系统。虽然Jen转运蛋白属于sialate:H + symporter(SHS)家族,但Ady2同源成员被分配到乙酸盐吸收转运蛋白(AceTr)家族。在这里,我们将后面的成员重新分类为ATO(醋酸转运蛋白直系同源物)。新的术语将有助于对这些转运蛋白的研究,以及对它们与念珠菌发病机理的相关性的分析。
更新日期:2020-06-30
down
wechat
bug