Suppression of unwanted motor responses can be disrupted by Parkinson's disease. People with Parkinson's (PwP) can show maladaptive reward-driven behaviours in the form of impulse control behaviours, which are associated with the use of the dopaminergic treatments used to alleviate the motor symptoms of the disease. However, the effects of Parkinson's itself on impulsive behaviour and control are unclear-empirical studies have yielded mixed findings, and some imaging studies have shown a functional deficit in the absence of a measurable change in behaviour. Here, we investigated the effects of Parkinson's on response activation and control by studying the dynamics of response in standard inhibitory control tasks-the Stop Signal and Simon tasks-using a continuous measure of response force. Our results are largely in favour of the conclusion that response inhibition appears to be intact in PwP, even when using a more sensitive measure of behavioural control relative to traditional button-press measures. Our findings provide some clarity as to the effects of Parkinson's on response inhibition and show continuous response force measurement can provide a sensitive means of detecting erroneous response activity in PwP, which could also be generalised to studying related processes in other populations.

中文翻译：

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连续的力测量显示帕金森氏病没有抑制性控制缺陷。

帕金森氏病可能会抑制不必要的运动反应。帕金森氏症（PwP）的人可以以冲动控制行为的形式表现出适应不良的奖励驱动行为，这与使用多巴胺能疗法减轻疾病的运动症状有关。然而，尚不清楚帕金森本身对冲动行为和控制的影响，经验研究得出的结论参差不齐，一些影像学研究表明，在行为没有可测量的变化的情况下功能缺陷。在这里，我们通过研究连续抑制力的标准抑制性控制任务（停止信号和西蒙任务）中的反应动力学，研究了帕金森氏症对反应激活和控制的影响。我们的结果在很大程度上支持以下结论：即使相对于传统的按钮按压措施，使用行为控制更敏感的措施，PwP中的反应抑制作用似乎仍然完整。我们的发现为帕金森氏症对反应抑制的影响提供了一些清晰的信息，并表明持续的反应力测量可以提供检测PwP中错误反应活性的灵敏手段，这也可以推广到研究其他人群的相关过程。