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Does adiponectin play a role in the pathogenesis of chronic spontaneous urticaria?
Central European Journal of Immunology ( IF 1.3 ) Pub Date : 2020-01-01 , DOI: 10.5114/ceji.2020.94678
Katarzyna Adamczyk 1 , Dominika Wcislo-Dziadecka 2 , Martyna Zbiciak-Nylec 1 , Ligia Brzezinska-Wcislo 1 , Zenon Brzoza 3, 4
Affiliation  

INTRODUCTION Chronic spontaneous urticaria constitutes an interdisciplinary problem and its pathogenesis is still a subject of debate. Overweight and hyperlipidemia are supposed to be related to chronic spontaneous urticaria. Fatty tissue can be the source of adipokines. AIM OF THE STUDY To assess the potential role of adiponectin in chronic spontaneous urticaria pathogenesis. MATERIAL AND METHODS The study included 52 chronic spontaneous urticaria patients and 43 healthy controls. The patients were divided into two subgroups: patients with wheals only, and patients with urticaria and an accompanying angioedema. The adiponectin concentration was measured in all studied subjects. RESULTS No statistically significant difference in adiponectin level was determined between the studied groups and subgroups. CONCLUSIONS We are among the first to present the results of study to determine a possible role of adipokines in chronic spontaneous urticaria pathogenesis. We did not observe any difference in adiponectin level. In our opinion, it is necessary to conduct further analyses in this field.

中文翻译:

脂联素在慢性自发性荨麻疹的发病机制中是否起作用?

引言 慢性自发性荨麻疹是一个跨学科问题,其发病机制仍存在争议。超重和高脂血症被认为与慢性自发性荨麻疹有关。脂肪组织可以是脂肪因子的来源。研究目的 评估脂联素在慢性自发性荨麻疹发病机制中的潜在作用。材料与方法 本研究包括 52 名慢性自发性荨麻疹患者和 43 名健康对照者。将患者分为两个亚组:仅有风团的患者,以及荨麻疹和伴随血管性水肿的患者。在所有研究对象中测量脂联素浓度。结果 研究组和亚组之间的脂联素水平没有统计学上的显着差异。结论 我们是第一个提出研究结果以确定脂肪因子在慢性自发性荨麻疹发病机制中的可能作用的人之一。我们没有观察到脂联素水平的任何差异。我们认为,有必要在该领域进行进一步的分析。
更新日期:2020-01-01
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