Atherosclerosis is a disease caused by an inflammatory response which involved the interaction between endothelial cells, macrophages and lymphocytes, and is closely related to IL-17 regulation. This study is important to investigate the activity of Agaricusblazei in modulating the immunological activity based on the profile of CD4+IL-17+, CD8+IL-17+, and CD11b+ IL-17+ in high-fat diet (HFD)-induced Balb/c mice. Mice in dietary groups were fed with HFD and then fed with A. blazei extract with three different doses including D1 (100 mg/kg BW), D2 (200 mg/kg BW), and D3 (400 mg/kg BW) once a day for 12 weeks. The cells were analyzed using flow cytometry and tested statistically with one-way ANOVA with α = 0.05 by using SPSS 16.00 software. The results showed that mice with HFD treatment had a higher level of Lp-PLA2 (atherosclerosis marker) compared with the control group (data not shown). The level of IL-17 in the atherosclerotic mice in the D1 group was significantly depleted compared to the control group. Of the three doses above, D1 may be an optimal dose to minimize or prevent the damage from atherosclerosis than the other doses.

中文翻译：

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姬松茸作为Balb / C小鼠动脉粥样硬化小鼠IL-17水平免疫调节剂的意义。

动脉粥样硬化是由炎症反应引起的疾病，其涉及内皮细胞，巨噬细胞和淋巴细胞之间的相互作用，并且与IL-17调节密切相关。这项研究对于研究姬松茸在调节高脂饮食诱导的高脂饮食中CD4 + IL-17 +，CD8 + IL-17 +和CD11b + IL-17 +的免疫学活性中的活性具有重要意义。 Balb / c小鼠。饮食组的小鼠先饲喂HFD，然后再饲以三种不同剂量的盲肠曲霉提取物，包括D1（100 mg / kg BW），D2（200 mg / kg BW）和D3（400 mg / kg BW）。一天，持续12周。使用流式细胞术分析细胞，并使用SPSS 16.00软件使用α= 0.05的单向ANOVA进行统计学测试。结果显示，与对照组相比，接受HFD治疗的小鼠的Lp-PLA2（动脉粥样硬化标记物）水平更高（数据未显示）。与对照组相比，D1组的动脉粥样硬化小鼠中的IL-17水平显着减少。在以上三个剂量中，D1可能是与其他剂量相比最小化或防止动脉粥样硬化损害的最佳剂量。