BackgroundThe Leuven Affect and Pleasure Scale (LAPS) is a depression outcome measure aiming to better reflect patient treatment expectations. We investigated the evolution of the LAPS and some comparator scales during antidepressant treatment and compared scores of remitters with scores of healthy controls.MethodsA total of 109 outpatients with Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) major depressive disorder were assessed over 8 weeks of antidepressant treatment. At baseline and after 2, 4, and 8 weeks, the LAPS as well as the Hamilton Depression Rating Scale (HAMD), the Snaith–Hamilton Pleasure Scale (SHAPS), the Positive and Negative Affect Scale (PANAS), and the Sheehan Disability Scale (SDS) were administered. Healthy controls consisted of 38 Italian adults and 111 Belgian students.ResultsCorrelations between baseline positive and negative affect were only moderate (R between −0.20 and −0.41). LAPS positive affect and hedonic tone showed higher correlations with LAPS cognitive functioning, overall functioning, meaningfulness of life, and happiness than HAMD scores or PANAS negative affect. HAMD remission was associated with normal levels of LAPS negative affect but with significantly lower levels of LAPS positive affect, hedonic tone, cognitive functioning, overall functioning, meaningfulness of life, and happiness. The scores on the latter subscales only reached healthy control scores when the HAMD approached a score of 0 or 1.ConclusionsThe standard definition of remission (HAMD cutoff of 7) is probably adequate for remitting negative mood, but not good enough for recovering positive mood, hedonic tone, functioning, or meaningfulness of life.

中文翻译：

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抑郁症的结局（一）：为什么症状缓解不够好

背景鲁汶情感和快乐量表 (LAPS) 是一种抑郁症结果测量方法，旨在更好地反映患者的治疗期望。我们调查了抗抑郁治疗过程中 LAPS 和一些比较量表的演变，并将汇款人的分数与健康对照的分数进行了比较。方法共有 109 名精神障碍诊断和统计手册第五版 (DSM-5) 重度抑郁症门诊患者进行了研究。评估超过 8 周的抗抑郁治疗。在基线和 2、4 和 8 周后，LAPS 以及汉密尔顿抑郁量表 (HAMD)、斯奈思-汉密尔顿快乐量表 (SHAPS)、积极和消极影响量表 (PANAS) 和希恩残疾量表（SDS）被管理。健康对照组由 38 名意大利成年人和 111 名比利时学生组成。结果基线正面和负面影响之间的相关性仅为中等（R 介于 -0.20 和 -0.41 之间）。LAPS 积极情绪和享乐基调与 LAPS 认知功能、整体功能、生活意义和幸福感的相关性高于 HAMD 评分或 PANAS 消极情绪。HAMD 缓解与正常水平的 LAPS 负面影响有关，但与 LAPS 积极影响、享乐基调、认知功能、整体功能、生活意义和幸福感水平显着降低有关。后一个分量表的分数只有在 HAMD 接近 0 或 1 分时才达到健康控制分数。结论缓解的标准定义（HAMD 截止值为 7）可能足以缓解消极情绪，但不足以恢复积极情绪，享乐基调，功能，