This note reflects on my collaborations with Nick Martin and the GenEpi group over the past 20 years. Over the past two decades, our work together has focused on gene mapping and understanding the genetic architecture of a wide range of traits with particular foci on migraine and common baldness. Our migraine research has included latent class and twin analyses cumulating in genome-wide association analyses which had identified 44 (34 new) risk variants for migraine. Leveraging these results through polygenic risk score analyses identified subgroups of patients likely to respond to triptans (an acute migraine drug), providing the first step toward precision medicine in migraine [Kogelman et al. (2019) Neurology Genetics, 5, e364].

中文翻译：

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偏头痛、人类遗传学和对科学的热情

这篇笔记反映了我在过去 20 年与 Nick Martin 和 GenEpi 小组的合作。在过去的二十年里，我们的合作主要集中在基因图谱上，并了解各种特征的遗传结构，尤其是偏头痛和常见的秃发。我们的偏头痛研究包括在全基因组关联分析中累积的潜在类别和双胞胎分析，这些分析确定了 44 种（34 种新的）偏头痛风险变异。通过多基因风险评分分析利用这些结果，确定了可能对曲坦类药物（一种急性偏头痛药物）有反应的患者亚组，为偏头痛的精准医疗迈出了第一步 [Kogelman 等人。(2019) 神经学遗传学，5，e364]。