Introduction: The International System for Reporting Serous Fluid Cytopathology (ISRSFC) has recently been announced. Pericardial effusion (PE) is a clinical manifestation of a large variety of both neoplastic and non-neoplastic conditions. Herein, we have applied the ISRSFC on reporting PE cytopathology and report our experience in a large academic institution. Method and Materials: After the Institutional Research Board approval, the electronic pathology database of a large academic institution was queried for PEs collected from January 2014 to January 2019. The diagnosis, patient demographics, and specimen volume were recorded for each case. The ISRSFC was applied and the cases were divided into 5 categories: nondiagnostic (ND), negative for malignancy (NFM), atypia of uncertain significance (AUS), suspicious for malignancy (SFM), and malignant (MAL). Each category was evaluated separately. Results: A total of 299 cases were identified, 162 females and 137 males. The age of the subjects ranged from less than a year to 89 years (average 51.25 years). The volume ranged from 3 to 1,700 mL (average 298 mL). There were 252 NFM (84.3%), 13 AUS (4.3%), 4 SFM (1.3%), and 30 MAL (10%) cases. Metastatic lung cancer followed by metastatic breast cancer were the most common malignancies involving pericardial fluid (PF). No cases were diagnosed as ND. However, no mesothelial cells were seen in 97 specimens (38% of the negative cases). None of these patients developed malignant PE in at least 6 months of follow-up. Conclusion: The ISRSFC is a user-friendly reporting system which is easily applicable on serous fluid including PF. The vast majority of PEs was benign (84.3%). Our study shows that the presence of mesothelial cells is not necessary for specimen adequacy in serous effusions as no mesothelial cells were identified in 38% of the negative cases. Metastatic lung carcinoma was the most common diagnosis of malignant effusions.
Acta Cytologica

中文翻译：

---

国际浆液细胞病理学报告系统（ISRSFC）在心包积液细胞学报告中的应用。

简介：最近宣布了国际浆液细胞病理学报告系统（ISRSFC）。心包积液（PE）是多种肿瘤性和非肿瘤性疾病的临床表现。在此，我们将ISRSFC应用于报告PE细胞病理学，并报告了我们在大型学术机构中的经验。方法和材料：在机构研究委员会批准后，向大型学术机构的电子病理数据库查询了2014年1月至2019年1月收集的PE。记录每个病例的诊断，患者统计学和样本量。应用ISRSFC，将病例分为5类：非诊断性（ND），恶性阴性（NFM），不确定性非典型性异型（AUS），可疑恶性（SFM）和恶性（MAL）。每个类别分别进行评估。结果：共鉴定出299例，女性162例，男性137例。受试者的年龄范围从不到一年到89岁（平均51.25岁）。体积范围从3到1,700 mL（平均298 mL）。有252例NFM（84.3％），13例AUS（4.3％），4例SFM（1.3％）和30例（10％）病例。转移性肺癌继之以转移性乳腺癌是涉及心包积液（PF）的最常见恶性肿瘤。没有病例被诊断为ND。但是，在97个标本中没有发现间皮细胞（阴性病例的38％）。这些患者至少在随访的6个月内没有发生恶性PE。结论：ISRSFC是一种用户友好的报告系统，可轻松应用于包括PF在内的浆液。绝大多数私立学校是良性的（84.3％）。我们的研究表明，浆膜积液中标本的充分性并不需要间皮细胞的存在，因为在38％的阴性病例中未发现间皮细胞。转移性肺癌是恶性积液最常见的诊断。
细胞学学报