Viruses hijack host cellular receptors and functions for replication, thereby posing a complication in identifying therapeutic targets. The CRISPR/Cas 9 platform has revolutionized gene-editing modalities in a wide range of cells and organisms with high potential in therapeutics. Recently, it has been put to work targeting human pathogenic viruses that interrupt receptors and functions with viral replication. This review encompasses major discoveries in CRISPR/Cas as an antiviral strategy. Additionally, challenges that demand consideration prior to its use in the clinic as part of the antiviral armamentarium are briefly addressed.

中文翻译：

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CRISPR/CAS9 介导的抗病毒活性：对抗病毒感染的工具。

病毒劫持宿主细胞受体并发挥复制功能，从而给确定治疗靶点带来了复杂性。CRISPR/Cas 9 平台在广泛的细胞和生物体中彻底改变了基因编辑方式，具有很高的治疗潜力。最近，它已开始针对人类病原性病毒进行工作，这些病毒会通过病毒复制中断受体和功能。本综述涵盖了 CRISPR/Cas 作为抗病毒策略的重大发现。此外，还简要讨论了在将其作为抗病毒设备的一部分用于临床之前需要考虑的挑战。