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Meiotic Behavior of Extra Sex Chromosomes in Patients with the 47,XXY and 47,XYY Karyotype and Its Ultimate Consequences for Spermatogenesis.
Critical Reviews in Eukaryotic Gene Expression ( IF 1.6 ) Pub Date : 2020-01-01 , DOI: 10.1615/critreveukaryotgeneexpr.2020026203
Furhan Iqbal 1
Affiliation  

Infertility is one of the most important and burning issues in present times, as a marked increase in the frequency of infertile cases has been observed all over the world. Chromosomal aneuploidy is among the known factors associated with infertility, and among sex chromosome aneuploidies, 47,XXY and 47,XYY constitute the most common class of chromosome abnormality in human live births. Considerable attention has been given to the somatic abnormalities associated with these conditions, but less is known about their meiotic progression; that is, how sex chromosome imbalance influences the meiotic process. It has been documented that men with the same underlying genetic cause of infertility do not present with uniform pathology, so it is informative to find out how meiotic progression differs in patients with similar chromosomal aneuploidy having different phenotypes. The importance of studying meiotic progression in patients with sex chromosome abnormalities has increased many fold with the introduction of assisted reproductive technologies that have made it possible for infertile men to become biological parents. Hence, exploring the possible consequences of sex chromosome aneuploidy for meiotic chromosome segregation is worthwhile. The objective of this review, in the context of current knowledge, is to discuss problems associated with fertility and progression of meiosis in two relatively common sex chromosome aneuploidies, 47,XXY and 47,XYY, reported in humans.

中文翻译:

47,XXY 和 47,XYY 核型患者额外性染色体的减数分裂行为及其对精子发生的最终后果。

不孕症是当今最重要和最紧迫的问题之一,因为在世界各地都观察到不孕症发生频率显着增加。染色体非整倍体是与不育相关的已知因素之一,在性染色体非整倍体中,47,XXY 和 47,XYY 是人类活产中最常见的一类染色体异常。人们对与这些疾病相关的躯体异常给予了相当多的关注,但对其减数分裂进程知之甚少。也就是说,性染色体失衡如何影响减数分裂过程。有文献记载,具有相同潜在不育遗传原因的男性并没有出现统一的病理学,因此,了解具有不同表型的相似染色体非整倍体患者的减数分裂进程有何不同是有益的。随着辅助生殖技术的引入,使不育男性成为亲生父母成为可能,研究性染色体异常患者减数分裂进程的重要性成倍增加。因此,探索性染色体非整倍体对减数分裂染色体分离的可能后果是值得的。本综述的目的是在现有知识的背景下讨论与人类报道的两种相对常见的性染色体非整倍体 47,XXY 和 47,XYY 的生育力和减数分裂进展相关的问题。随着辅助生殖技术的引入,使不育男性成为亲生父母成为可能,研究性染色体异常患者减数分裂进程的重要性成倍增加。因此,探索性染色体非整倍体对减数分裂染色体分离的可能后果是值得的。本综述的目的是在现有知识的背景下讨论与人类报道的两种相对常见的性染色体非整倍体 47,XXY 和 47,XYY 的生育力和减数分裂进展相关的问题。随着辅助生殖技术的引入,使不育男性成为亲生父母成为可能,研究性染色体异常患者减数分裂进程的重要性成倍增加。因此,探索性染色体非整倍体对减数分裂染色体分离的可能后果是值得的。本综述的目的是在现有知识的背景下讨论与人类报道的两种相对常见的性染色体非整倍体 47,XXY 和 47,XYY 的生育力和减数分裂进展相关的问题。探索性染色体非整倍体对减数分裂染色体分离的可能后果是值得的。本综述的目的是在现有知识的背景下讨论与人类报道的两种相对常见的性染色体非整倍体 47,XXY 和 47,XYY 的生育力和减数分裂进展相关的问题。探索性染色体非整倍体对减数分裂染色体分离的可能后果是值得的。本综述的目的是在现有知识的背景下讨论与人类报道的两种相对常见的性染色体非整倍体 47,XXY 和 47,XYY 的生育力和减数分裂进展相关的问题。
更新日期:2020-01-01
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