Many intricate pathways contribute to the timely control of gene expression during development. Polycomb repressive complexes (PRC1 and PRC2) and long non-coding RNAs (lncRNAs) are players associated with gene repression in various developmental processes such as X chromosome inactivation (XCI) and genomic imprinting. Historically, lncRNAs were proposed to directly recruit PRC2. However, recent evidence suggests that promiscuous interactions between PRC2 and RNA fine-tune the function of the complex through a multiplicity of mechanisms. A PRC2-recruitment model was definitively overturned in the paradigm of XCI by Xist RNA, being replaced by a novel mechanism which puts PRC1 in the spotlight. This review focuses on these recent advances in understanding the interplay between RNA and Polycomb complexes for gene expression control.

中文翻译：

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RNA调控Polycomb的许多方面。

许多复杂的途径有助于在发育过程中及时控制基因表达。聚梳抑制复合物（PRC1和PRC2）和长非编码RNA（lncRNA）是在各种发育过程中与基因阻抑相关的参与者，例如X染色体失活（XCI）和基因组印迹。从历史上看，lncRNA被提议直接募集PRC2。但是，最近的证据表明，PRC2和RNA之间的混杂相互作用通过多种机制微调了复合物的功能。Xist RNA在XCI范式中彻底颠覆了PRC2招聘模型，取而代之的是一种新颖的机制，使PRC1受到关注。这篇综述着重于这些最新进展，以了解用于基因表达控制的RNA和Polycomb复合物之间的相互作用。